Evidence map›Paper›PMID 40375756›Full record

ArticleContact dermatitis2025

Thresholds for Contact Allergy to a Rubber Accelerator: TETD-Determined by Serial Dilution Patch Testing and a Simulated Glove-Use Model.

Christoffer Kursawe Larsen, Jeanne D Johansen, Claus Zachariae, Cecilia Svedman, Ola Bergendorff, Charlotte G Mortz, Jakob F B Schwensen

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Contact dermatitis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06042309 (Improving the Diagnosis and Prevention of Contact Allergy to Rubber Accelerators), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06042309 nacompletednot on this map

Improving the Diagnosis and Prevention of Contact Allergy to Rubber Accelerators

TypeinterventionalSponsorNational Allergy Research Center, DenmarkRan2024 to 2024Enrolled18ConditionsContact AllergyArmsRubber accelerators and control chamber/solution for NON-SLS group, SLS, Rubber accelerators and control chamber/solution for SLS group, Patch test on back
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christoffer Kursawe LarsenNational Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital, Hellerup, Denmark.ORCID https://orcid.org/0000-0003-2989-9198
Jeanne D JohansenNational Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital, Hellerup, Denmark.ORCID https://orcid.org/0000-0002-3537-8463
Claus ZachariaeNational Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital, Hellerup, Denmark.
Cecilia SvedmanDepartment of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.ORCID https://orcid.org/0000-0003-4797-0269
Ola BergendorffDepartment of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.
Charlotte G MortzDepartment of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0001-8710-0829
Jakob F B SchwensenNational Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital, Hellerup, Denmark.ORCID https://orcid.org/0009-0007-9756-656X

Funding

The Danish Environmental Protection Agency under the Ministry of Environments and Food
6 · The paper itself

Abstract

backgroundRubber accelerators found in rubber gloves may cause contact allergy and thus allergic contact dermatitis.

objectivesTo investigate which doses of tetraethylthiuram disulfide (TETD) elicit allergic contact dermatitis by patch testing and in a repeated occluded application test simulating glove use. PATIENTS AND

methodsA multicentre study was conducted. Eight patients with contact allergy to TETD and eight controls comprised the study group. Doses of TETD 1% (400 μg/cm

resultsThree patients (3/8) reacted to the lowest TETD dose of 0.0041% (1.6 μg/cm

conclusionA content of 0.75 μg/cm

trial registrationClinicalTrial.gov identifier: NCT06042309.

Indexed as

Dermatitis, Allergic ContactDermatitis, OccupationalGloves, ProtectiveHand DermatosesRubberThiramAdultFemaleHumansMaleMiddle AgedPatch TestsRubberThiramallergic contact dermatitiscontact allergyrepeated occluded application testrubber acceleratorTETDtetraethylthiuram disulfideZDECzinc diethyldithiocarbamate

Identifiers

PMID40375756
PMCPMC12223932

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.