Association between perinatal complications and venous thromboembolism in postpartum women.

Background: Several studies have been conducted on the risk factors for but there is a lack of research on the relationship between perinatal complications and venous thromboembolism (VTE) in large samples of Asian populations. This study aimed to systematically investigate the relationship between perinatal complications and VTE in Asian populations. Methods: This retrospective study included 40 213 women delivering singleton pregnancies. We compared the perinatal complications between the two groups, including hypertensive disorder complicating pregnancy (HDCP), preeclampsia, maternal fever before delivery, preterm birth, intrahepatic cholestasis of pregnancy, gestational diabetes mellitus, meconium-stained amniotic fluid, postpartum hemorrhage, and premature rupture of membranes. Furthermore, we conducted a logistic regression analysis to explore the relationship between VTE and the risk of adverse perinatal outcomes. Results: We observed that mothers in the VTE group were significantly more likely to have been aged 35 years or older (28.79 vs. 17.23%, P = 0.013) and to have undergone cesarean delivery (89.39 vs. 48.19%, P < 0.000) compared to the non-VTE group. Further logistic regression analysis revealed that, regardless of adjustment for confounding factors, the VTE group was significantly associated with HDCP, preeclampsia, maternal fever before delivery, preterm birth, and intrahepatic cholestasis of pregnancy, with statistically significant differences. Conclusions: Compared to the non-VTE group, the VTE group was more likely to be older (≥35 years) and exhibited a higher cesarean section rate. Additionally, the VTE group was significantly associated with increased odds of HDCP, preeclampsia, maternal fever before delivery, premature delivery and intrahepatic cholestasis of pregnancy compared to the non-VTE group, regardless of whether the confounding factors were adjusted.