Evidence map›Paper›PMID 40375621›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2025

Design, synthesis and biological evaluation of novel urolithin derivatives targeting liver cancer cells.

Mi Tian, Lirong Zhao, Yu Lan, Chen Li, Yipeng Ling, Benhong Zhou

Erratum issuedAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Mi TianDepartment of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lirong ZhaoDepartment of Pharmacy, General Hospital of The Yangtze River Shipping, Wuhan, China.
Yu LanDepartment of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
Chen LiDepartment of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
Yipeng LingDepartment of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.
Benhong ZhouDepartment of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We designed and synthesised 22 new urolithin derivatives (UDs) based on methyl-urolithin A (mUA) to identify anti-cancer drugs with high efficacy and low toxicity and evaluated their anti-cancer activities

Indexed as

Antineoplastic AgentsCoumarinsDrug DesignLiver NeoplasmsApoptosisCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHep G2 CellsHumansMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsCoumarinsanti-cancer activityapoptosiscell cyclehepatocellular carcinomaproliferationUrolithin derivatives

Identifiers

PMID40375621
PMCPMC12086910

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.