Evidence map›Paper›PMID 40375605›Full record

ArticleCell proliferation2025

Deciphering the Immunomodulatory Function of GSN

Shan Li, Xinwei Zhou, Haoqian Feng, Kangbo Huang, Minyu Chen, Mingjie Lin, Hansen Lin, Zebing Deng, Yuhang Chen, Wuyuan Liao and 9 more

Abstract read
In one paragraph

Article in Cell proliferation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Shan LiDepartment of Urology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID https://orcid.org/0009-0007-5016-5144
Xinwei ZhouDepartment of Urology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Haoqian FengDepartment of Urology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Kangbo HuangDepartment of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Minyu ChenDepartment of Urology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Mingjie LinDepartment of Urology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Hansen LinDepartment of Urology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Zebing DengDepartment of Urology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yuhang ChenDepartment of Geniturinary Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Wuyuan LiaoDepartment of Urology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Zhengkun ZhangDepartment of Urology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Jinwei ChenDepartment of Urology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Bohong GuanDepartment of Urology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Tian SuDepartment of Pediatric Intensive Care Unit (PICU), Guangdong Provincial People's Hospital Heyuan Hospital, Heyuan, Guangdong, China.
Zihao FengDepartment of Urology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Guannan ShuDepartment of Urology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou Institute of Pediatrics, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, China.
Anze YuDepartment of Urology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Yihui PanDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Liangmin FuDepartment of Urology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.

Funding

China Postdoctoral Science Foundation 2023M730374China Postdoctoral Science Foundation 2024M763793Leading Innovative Talents in Changzhou CQ20220129Medical Scientific Research Foundation of Guangdong Province of China A2025206National Natural Science Foundation of China 82403606National Natural Science Foundation of China 82403968Natural Science Foundation of Guangdong Province 2025A1515010988Natural Science Foundation of Jiangsu Province BK20240342Natural Science Research Project of Higher Education Institutions in Jiangsu Province 23KJB320018Research Foundation of Guangzhou Women and Children's Medical Center for Clinical Doctor
6 · The paper itself

Abstract

The heterogeneity of cancer-associated fibroblasts (CAFs) could affect the response to immune checkpoint inhibitor (ICI) therapy. However, limited studies have investigated the role of inflammatory CAFs (iCAFs) in ICI therapy using pan-cancer single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics sequencing (ST-seq) analysis. We performed pan-cancer scRNA-seq and ST-seq analyses to identify the subtype of GSN

Indexed as

Cancer-Associated FibroblastsCarcinoma, Renal CellImmunotherapyKidney NeoplasmsAnimalsCell Line, TumorGene Expression ProfilingHumansImmune Checkpoint InhibitorsInflammationMiceSingle-Cell AnalysisTranscriptomeTumor MicroenvironmentImmune Checkpoint Inhibitorscancer‐associated fibroblastsclear cell renal cell carcinomaimmune checkpoint inhibitorsmachine learningmulti‐omics analysispan‐cancer analysis

Identifiers

PMID40375605
PMCPMC12686145

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.