ArticleJournal of intellectual disability research : JIDR2025
A Further Characterisation of the Neuropsychological Profile, Social Perception, and Academic Skills in Sotos Syndrome.
Article in Journal of intellectual disability research : JIDR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Peripersonal space and interpersonal distance as windows onto multisensory body representation in adolescents with overgrowth syndromes.Frontiers in human neuroscience · 2026Article
- A Further Characterisation of the Neuropsychological Profile, Social Perception, and Academic Skills in Sotos Syndrome.Journal of intellectual disability research : JIDR · 2025Article
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6 authors.
Funding
Abstract
backgroundSotos syndrome (SoS) is a rare genetic disorder characterised by physical overgrowth and by frequent intellectual disability and comorbidity with neurodevelopmental disorders. A recent study documented a specific cognitive profile of SoS. However, further research is needed to replicate and expand these findings to other neuropsychological domains, including social perception. Moreover, numeracy has long been considered as a weakness in SoS, but inconsistent evidence asks for a further assessment of academic skills.
methodThis single-cohort, cross-sectional study enrolled 28 participants with SoS aged 5-18 years, who underwent a comprehensive neuropsychological assessment. Moreover, a school-age subgroup was administered with standardised tests assessing academic skills.
resultsThe neuropsychological profile was characterised by lowest scores in both language and visuospatial abilities and highest scores in memory for faces. Greatest difficulties were observed in rapid verbal production, visuospatial memory and graphomotor control. Neither attention and executive functions nor social perception skills were relative weaknesses or strengths of the profile. An exploratory analysis revealed that the comorbidity with autism spectrum disorder and/or attention-deficit/hyperactivity disorder did not result in a different neuropsychological profile. A large part of the sample had poor mathematics skills, and only one participant did not display any difficulties in mathematics.
conclusionsThis study extends the previous characterisation of the SoS cognitive profile and documents a prevalent difficulty in mathematics skills. Notably, social perception does not emerge as selectively impaired in SoS. The results have important implications for tailoring rehabilitative interventions, school adjustment and daily living of children and adolescents with SoS.
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