Trial reportScandinavian journal of medicine & science in sports2025
Effects of Blood-Flow Restricted Resistance Exercise Versus Neuromuscular Exercise on Mechanical Muscle Function in Adults With Chronic Knee Osteoarthritis-A Secondary Analysis From a Randomized Controlled Trial.
Trial report in Scandinavian journal of medicine & science in sports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of blood flow restriction exercise interventions on patellofemoral pain syndrome: a systematic review and meta-analysis.Frontiers in physiology · 2026Pooled it
- Effects of Blood-Flow Restricted Resistance Exercise Versus Neuromuscular Exercise on Self-Perceived Knee Pain, Function, Quality of Life, and Objective Measures of Functional Performance and Pain Sensitization in Adults With Knee Osteoarthritis-A Randomized Controlled Trial.Scandinavian journal of medicine & science in sports · 2025Trial
- Occlusion pressure and blood pressure adaptations following low-load blood flow restriction training versus moderate-load training: a pilot randomized clinical trial in patients with knee osteoarthritis.Frontiers in physiology · 2025Trial
- Unraveling the pathogenic mechanisms of osteoarthritis and obesity: An integration of GWAS, cellular specificity, and spatial transcriptomics.Osteoarthritis and cartilage open · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Knee osteoarthritis (knee OA) is a prevalent condition worldwide. Globally recognized rehabilitation guidelines for knee OA include patient education and neuromuscular exercises (NEMEX). While heavy-load resistance exercise (70%-90% 1RM) often induces pain with knee OA, low-load exercise (20%-40% 1RM) combined with partial blood-flow restriction (BFR-RE) has been introduced without inducing excessive knee joint pain. The present study aimed to compare the effects of NEMEX and BFR-RE on mechanical muscle function in knee OA individuals. Ninety-six participants (age 56.7 ± 7.6; 47 males, 49 females) with symptomatic, radiographic knee OA were randomized to free-flow land-based NEMEX or unilateral machine-based BFR-RE. Both groups exercised biweekly for 12 weeks while also receiving patient education. Outcomes measured from baseline to 12 weeks included maximal isometric knee extensor strength (MVIC), rate of force development (RFD), maximal leg extensor power (LEP), and cross-sectional area (mCSA) of rectus femoris (RF) and vastus lateralis (VL). Significant (p < 0.01) within-group improvements from baseline to 12 weeks were observed in both groups for MVIC (BFR-RE: +0.4 vs. NEMEX: +0.1 Nm/kg), LEP (+0.6 vs. +0.2 W/kg), mCSA for RF (+1.8 vs. +0.6 cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.