ArticleBMC oral health2025
Unravelling the role of interleukin-6 in regulating dental stem cell behaviour: a scoping review.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Dental Pulp Stem Cells for the Management of Plaque Biofilm-Associated Infections : A Review.International dental journal · 2026Review
- Exploring vitamin K2 and B12 as bioactive micronutrients for dentin conditioning in regenerative endodontics procedures.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Applicability of Whole Blood Monocyte Activation Test for Endotoxin Activity Assessment in Hydroxyapatite-Based Ceramics.Bioengineering (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInterleukin-6 (IL-6) functions as a pro-inflammatory and anti-inflammatory cytokine. IL-6 plays a pivotal role in a multitude of biological processes. This scoping review aimed to explore the impact of IL-6 on the biological responses of dental tissue-derived mesenchymal stem cells.
methodsThe literature databases (PubMed and Scopus) were searched utilising specific design keywords. The criteria for inclusion encompassed (1) original research investigations that examined the effect of IL-6 on dental stem cells through the introduction of exogenous IL-6, overexpression, or knockdown expression, and (2) publications authored in the English language. The articles that conformed to these criteria were subsequently compiled for comprehensive full-text analysis and data extraction.
resultsThe literature search identified 323 articles, including 99 and 224 pertinent publications from the PubMed and Scopus databases, respectively. After screening, 14 publications satisfied the inclusion criteria and were subsequently selected for data extraction. The findings demonstrated that IL-6 regulates stemness maintenance, cellular proliferation, and differentiation towards osteogenic, adipogenic, chondrogenic, and neurogenic lineages in dental tissue-derived mesenchymal stem cells.
conclusionIL-6 modulates the biological activities of mesenchymal stem cells, particularly those derived from dental tissues. Nevertheless, the inconsistencies observed across various studies may be attributable to a range of factors, including the heterogeneity inherent in stem cell sources, the stages of differentiation, the conditions of culture, and the particularities of experimental design.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.