Evidence map›Paper›PMID 40375219›Full record

ArticleBMC pediatrics2025

Association of STAT6 gene polymorphism with atopic asthma among Yemeni children in Sana'a city, Yemen.

Haitham Abdulwahab Masood, Arwa Mohammed Othman, Najla Nasr Addin Al-Sonboli, Faiza Abdulnoor Ghlab, Naif Mohammed Al-Haidary, Muhanna M Al-Shaibani

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Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Haitham Abdulwahab MasoodDepartment of Medical Microbiology and Immunology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen. haithammasood11@gmail.com.
Arwa Mohammed OthmanDepartment of Medical Microbiology and Immunology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.ORCID 0000-0001-5893-2247
Najla Nasr Addin Al-SonboliDepartment of Pediatrics, Faculty of Medicine and Health Sciences, Sana University, Sana'a, Yemen.
Faiza Abdulnoor GhlabDepartment of Medical Microbiology and Immunology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.
Naif Mohammed Al-HaidaryDepartment of Medical Microbiology and Immunology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.ORCID 0009-0004-4389-1285
Muhanna M Al-ShaibaniDepartment of Medical Microbiology and Immunology, Faculty of Medicine and Health Sciences, Taiz University, Taiz, Yemen.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAsthma is the most common chronic illness in children and is characterized by airway hyperresponsiveness, increased production of mucus, and significant inflammation. The signal transducer and activator of transcription 6 (STAT6) is a crucial gene in immune response, specifically in atopic reactions. It plays a role in the IL-4 and IL-13 signaling pathways in asthma and allergies.

objectiveThis study aimed to determine the association between the STAT6 rs324011 gene polymorphism and atopic asthma among Yemeni children as well as to investigate the impact of the STAT6 rs324011 polymorphism on IL-13, total IgE, and eosinophils.

methodsThis study included 75 Yemeni children diagnosed with bronchial asthma and 75 healthy controls matched for age and sex. The STAT6 polymorphism (rs324011) was genotyped using RFLP PCR, the IL-13 serum level was measured via ELISA, and the serum IgE level was measured via electrochemiluminescence.

resultsUnder a recessive model, the TT genotype of the STAT6 polymorphism rs324011 was significantly associated with an increased risk of atopic asthma compared to the CC and CT genotypes (χ

conclusionThe TT genotype and T allele of the STAT6 rs324011 polymorphism may be associated with increased susceptibility to pediatric asthma among Yemeni children.

Indexed as

AsthmaPolymorphism, Single NucleotideSTAT6 Transcription FactorAdolescentCase-Control StudiesChildChild, PreschoolEosinophilsFemaleGenetic Predisposition to DiseaseGenotypeHumansImmunoglobulin EInterleukin-13MaleYemenImmunoglobulin EInterleukin-13STAT6 protein, humanSTAT6 Transcription FactorAtopic asthmaEosinophilsIgEIL-13rs324011 SNP

Identifiers

PMID40375219
PMCPMC12080117

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