ArticleBMC musculoskeletal disorders2025
Incidence of deep venous thrombosis following medial opening-wedge high tibial osteotomy for varus knee osteoarthritis: a retrospective study.
Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- USP25 stabilises GLI1 through K48-linked deubiquitination within a reciprocal regulatory circuit in osteoarthritis models.Clinical and translational medicine · 2026Article
- Risk factors for postoperative ecchymosis after medial open-wedge high tibial osteotomy: an exploratory analysis of thromboelastography parameters.BMC surgery · 2026Article
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6 authors.
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Abstract
purposeDeep venous thrombosis (DVT) is a common yet underexplored complication following medial opening-wedge high tibial osteotomy (MOWHTO) for medial compartment knee osteoarthritis. Existing studies report inconsistent findings due to methodological differences and patient heterogeneity. This study aims to determine the incidence and risk factors for DVT after MOWHTO.
methodsWe retrospectively reviewed patients who underwent MOWHTO for medial compartment knee osteoarthritis with varus deformity between January 2019 and September 2023. Patients were classified into DVT and non-DVT groups based on Doppler ultrasonography findings. Univariate analysis was performed to compare demographics, lifestyle factors, comorbidities, surgical details, and laboratory results on postoperative day 1 between the DVT and non-DVT groups. Receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to evaluate the predictive performance of laboratory indices for DVT. Multivariate logistic regression model identified independent risk factors for DVT.
resultsOf the 421 patients (median age: 56 years, interquartile range: 52-61 years; 146 males), 55 (13.1%) developed postoperative DVT. The incidence rates for isolated calf muscle vein thrombosis (ICMVT), deep calf vein thrombosis (DCVT), and proximal DVT was 10.7%, 1.9% and 0.5%, respectively. Most laboratory indexes demonstrated non-significant (P > 0.05) or poor (AUC < 0.70) predictive performance, except for AT III and FDP (p = 0.022, 0.033, respectively). The multivariate logistic regression analyses showed female (OR, 2.23; 95% CI, 1.09 to 4.63), diabetes (OR, 2.47; 95% CI, 1.15 to 5.40) and hyperlipidemia (OR, 1.91; 95% CI, 1.14 to 3.68) were significantly associated with postoperative DVT.
conclusionThis study identified a high incidence of DVT following MOWHTO and demonstrated that female sex, diabetes and hyperlipidemia were significant risk factors. These findings may inform better risk assessment, stratification and management of DVT. CLINICAL TRIAL NUMBER: Not applicable.
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