Evidence map›Paper›PMID 40375173›Full record

ArticleBMC public health2025

Association between maternal exposure to cumulative childhood trauma and offspring childhood trauma and depressive symptoms among Chinese adolescents.

Yaru Zhang, Yuqiong He, Zhenpeng Xue, Jianchang Xu, Yumeng Sun, Shiqi Song, Ling Lin, Jianping Lu, Xuerong Luo, Jianbo Liu

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In one paragraph

Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Yaru Zhang *Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, the Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Yuqiong He *Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, the Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Zhenpeng XueDepartment of Child Psychiatry of Shenzhen Kangning Hospital, Shenzhen Clinical Research Center for Mental Disorders, Shenzhen Mental Health Center, Shenzhen, 518003, China.
Jianchang XuDepartment of Child Psychiatry of Shenzhen Kangning Hospital, Shenzhen Clinical Research Center for Mental Disorders, Shenzhen Mental Health Center, Shenzhen, 518003, China.
Yumeng SunDepartment of Child Psychiatry of Shenzhen Kangning Hospital, Shenzhen Clinical Research Center for Mental Disorders, Shenzhen Mental Health Center, Shenzhen, 518003, China.
Shiqi SongDepartment of Child Psychiatry of Shenzhen Kangning Hospital, Shenzhen Clinical Research Center for Mental Disorders, Shenzhen Mental Health Center, Shenzhen, 518003, China.
Ling LinDepartment of Child Psychiatry of Shenzhen Kangning Hospital, Shenzhen Clinical Research Center for Mental Disorders, Shenzhen Mental Health Center, Shenzhen, 518003, China.
Jianping LuDepartment of Child Psychiatry of Shenzhen Kangning Hospital, Shenzhen Clinical Research Center for Mental Disorders, Shenzhen Mental Health Center, Shenzhen, 518003, China.
Xuerong LuoDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, the Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China. luoxuerong@csu.edu.cn.
Jianbo LiuDepartment of Child Psychiatry of Shenzhen Kangning Hospital, Shenzhen Clinical Research Center for Mental Disorders, Shenzhen Mental Health Center, Shenzhen, 518003, China. jianboliu@aliyun.com.

Funding

Fund of the Science and Technology Planning Project of Shenzhen Municipality 20210617155253001Sanming Project of Medicine in Shenzhen SZSM202311025Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties SZGSP013STI 2030-Major Projects 2022ZD0209102The China Postdoctoral Science Foundation 2019M650358the Science and Technology Innovation Committee of Shenzhen JCYJ20190809155019338
6 · The paper itself

Abstract

backgroundThis study aimed to explore the effect of maternal exposure to cumulative childhood trauma (CT) on offspring CT and depressive symptoms.

methodsA total of 3672 mothers and their 3672 adolescent offspring who completed the questionnaires were included in this study. CT was assessed using the Childhood Trauma Questionnaire Short Form, while depressive symptoms in adolescents were assessed using the Center for Epidemiological Studies Depression Scale.

resultsAmong the 3672 maternal respondents, 1397 (38.04%) reported ever having experienced CT and 463 (12.61%) reported ≥ 2 types of CT. As shown by logistic regression analysis, having a mother who was exposed to 1 or ≥ 2 types of CT was a risk factor for offspring CT exposure in the overall sample of adolescents, as well as male and female adolescent subgroups, relative to those whose mothers were not exposed to CT. Offspring emotional neglect mediated the relationship between maternal exposure to cumulative CT and offspring depressive symptoms among male and female adolescents, while offspring physical neglect mediated the relationship between maternal exposure to cumulative CT and offspring depressive symptoms among male adolescent offspring, as the indirect paths did not include 0.

conclusionMaternal exposure to cumulative CT may affect the severity of CT in their adolescent offspring, which indirectly impacts adolescents' depressive symptoms.

Indexed as

Adverse Childhood ExperiencesDepressionMaternal ExposureMothersAdolescentAdultChildChinaEast Asian PeopleFemaleHumansMaleRisk FactorsSurveys and QuestionnairesChildhood traumaDepressive symptomsMaternalMediation modelOffspring

Identifiers

PMID40375173
PMCPMC12080020

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.