Evidence map›Paper›PMID 40375123›Full record

ArticleBMC genomics2025

Identification of lncRNAs involved in the hair follicle cycle transition of cashmere goats in response to photoperiod change.

Min Yang, Yingying Li, Qianqian Liang, Huajiao Dong, Yuehui Ma, Göran Andersson, Erik Bongcam-Rudloff, Hafiz Ishfaq Ahmad, Xuefeng Fu, Jilong Han

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Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Biomolecules · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Min Yang *College of Animal Science and Technology, Shihezi University, Shihezi, 832061, China.
Yingying Li *College of Animal Science and Technology, Shihezi University, Shihezi, 832061, China.
Qianqian LiangCollege of Animal Science and Technology, Shihezi University, Shihezi, 832061, China.
Huajiao DongCollege of Animal Science and Technology, Shihezi University, Shihezi, 832061, China.
Yuehui MaInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
Göran AnderssonDepartment of Animal Biosciences, Swedish University of Agricultural Sciences, 75007, Uppsala, Sweden.
Erik Bongcam-RudloffDepartment of Animal Biosciences, Swedish University of Agricultural Sciences, 75007, Uppsala, Sweden.
Hafiz Ishfaq AhmadDepartment of Animal Breeding and Genetics, Faculty of Veterinary and Animal Sciences, Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan.
Xuefeng FuInstitute of Animal Science, Xinjiang Academy of Animal Sciences, Urumqi, 830011, China.
Jilong HanCollege of Animal Science and Technology, Shihezi University, Shihezi, 832061, China. hanjilong@shzu.edu.cn.

Funding

International Science and Technology Cooperation Project of Shihezi University No. GJHZ202307the National Natural Science Foundation of China NO.31802045the National Natural Science Foundation of China No. 32060745the Open Project of State Key Laboratory of Animal Biotech Breeding 2024SKLAB 6-107
6 · The paper itself

Abstract

backgroundCashmere goats, as one of the important domesticated animal species, are known for their high-quality fiber. The growth of cashmere has seasonal variations caused by photoperiodic changes, but the molecular genetic mechanisms underlying this phenotype including the functional role of long non-coding RNAs (lncRNA) is still poorly understood.

resultsIn this study, we analyzed the RNA-seq dataset of 39 Cashmere goat skin samples including all different growth stages and identified 1591 lncRNAs. These lncRNAs exhibited growth stage-specific expression patterns. Combining shortened light and hair follicle growth cycles, we found that 68% of differentially photo-responsive lncRNAs showed similar expression trends during transition phase I (early anagen to anagen phase). This suggests that the mechanism of light-controlled induction of hair follicles from early anagen to anagen is similar to that of transition phase I. According to weighted gene co-expression network analyses (WGCNA) analysis, it was found that two gene clusters and 10 hub lncRNAs participated in the transformation of hair follicle cycle, inducing hair follicles to enter the full growth phase in advance. These hub lncRNAs may regulate the development cycle of hair follicles through cis- or trans-regulation on clock genes, SLC superfamily genes, fibroblast growth factor genes.

conclusionsThis study identified the key lncRNAs and target genes probably participating in the transformation of hair follicle cycle. This study will help further elucidate the role of lncRNAs in the hair follicle cycle and development.

Indexed as

GoatsHair FolliclePhotoperiodRNA, Long NoncodingAnimalsGene Expression ProfilingGene Regulatory NetworksRNA, Long NoncodingCashmere goatHair follicle cycleLncRNAShortened photoperiodTranscriptomic analysisWGCNA

Identifiers

PMID40375123
PMCPMC12080124

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.