Evidence map›Paper›PMID 40375072›Full record

ArticleBMC veterinary research2025

IncI2 plasmid transfer and changes of intestinal microbiota in mice under β-lactam antibiotic pressure.

Kaidi Liu, Junqi Liu, Yuting Su, Minge Wang, Tengfei Long, Liangxing Fang, Yufeng Zhou, Jian Sun, Xiaoping Liao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kaidi LiuNational Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, P. R. China.
Junqi LiuNational Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, P. R. China.
Yuting SuNational Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, P. R. China.
Minge WangSchool of Agricultural Science and Engineering, Liaocheng University, No.1 Hunan Road, Liaocheng, Shandong, 252000, China.
Tengfei LongNational Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, P. R. China.
Liangxing FangNational Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, P. R. China.
Yufeng ZhouNational Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, P. R. China.
Jian SunNational Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, P. R. China.
Xiaoping LiaoNational Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, P. R. China. xpliao@scau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundβ-lactam antibiotics represent the most widely utilized class of antimicrobial agents in livestock and poultry breeding. However, the effects of β-lactam antibiotics on conjugation transfer of IncI2 plasmids and the homeostasis of the mouse intestinal microbiota have not been thoroughly investigated.

resultsThe results revealed that the transfer of IncI2 plasmid was the highest for intra-specific E. coli and inter-specific transfer to Salmonella and K. pneumoniae occurred at much lower levels in the absence of β-lactam antibiotic selective pressure. Furthermore, inter-species and intra-species transfer of IncI2 plasmid was enhanced in the presence of sub-MIC levels of amoxicillin/clavulanate and cephalexin whereas ampicillin promoted only inter-species transfer. These results were consistent with in vivo observations where amoxicillin/clavulanate and cephalexin but not ampicillin promoted conjugation. Meanwhile, the intestinal microbiota was also disturbed following antibiotic treatment and Proteobacteria abundance increased while Bacteroides decreased. The gut microbiota could also be partially restored to initial levels after antibiotic cessation for 14 days.

conclusionsThese findings highlight the potential risk of β-lactam antibiotics in promoting the spread of resistance plasmids and causing disruption to the intestinal microbiota.

Indexed as

Anti-Bacterial Agentsbeta-LactamsGastrointestinal MicrobiomePlasmidsAnimalsEscherichia coliKlebsiella pneumoniaeMiceSalmonellaAnti-Bacterial Agentsbeta-LactamsAntibiotic resistanceConjugation transferIncI2 plasmidIntestinal microbiotaβ-lactam antibiotics

Identifiers

PMID40375072
PMCPMC12080001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.