ArticleEndocrine2025
Parathyroid weight estimation: beyond ellipsoid volume.
Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeParathyroid weight is a simple, robust functional status indicator and cornerstone of gross/intraoperative assessment, though sometimes unobtainable. We evaluate models to estimate weight from size and create an online calculator.
methodsActual weights (AW), cellularity, prosector identity and size were prospectively collected for 124 parathyroids (111 hypercellular, 13 normocellular) in 76 patients (4-6/2023). Simple volumetric weight estimates (VWE) for: ellipsoid, capsular, the novel capsuloid, and box shapes were compared with AW. Multiple linear regression (MLR) was performed with internal (k-fold) validation and external validation on an archival cohort (263 adenomas, 2016-2022). Subsets with surgeon's weight estimates, serum values, and microscopic surface area measured using the QuPath surface area tool were correlated with AW.
resultsThe optimal MLR model included capsuloid VWE, cellularity, and prosector identity (R
conclusionAn online calculator modeling capsuloid VWE and cellularity is a good predictor of AW. Variance in prosector measurements is important but impractical to model. Surgeon's estimates were quite accurate, emphasizing the value of this skill.
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