Evidence map›Paper›PMID 40374943›Full record

Trial reportScientific reports2025

A randomised trial of pleuran in paediatric acute gastroenteritis.

Katarzyna Wzorek-Łyczko, Anna Piwowarczyk, Weronika Woźniak, Ernest Kuchar, Henryk Szymański

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter StudyEquivalence Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03988257 (The Effectiveness of Pleuran in Treatment of Acute Gastroenteritis in Children- a Randomized, Placebo-controlled, Double-blind Trial), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03988257 phase4completednot on this map

The Effectiveness of Pleuran in Treatment of Acute Gastroenteritis in Children- a Randomized, Placebo-controlled, Double-blind Trial

TypeinterventionalSponsorMedical University of WarsawRan2019 to 2022Enrolled27ConditionsDiarrhoea, AcuteArmsImunoglukan PH4, Placebo (vitamin C syrup)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Katarzyna Wzorek-ŁyczkoThe Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, 63A Żwirki & Wigury Street, Warsaw, 02-091, Poland. katarzynawzorek@vp.pl.ORCID http://orcid.org/0000-0003-0353-8909
Anna PiwowarczykThe Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, 63A Żwirki & Wigury Street, Warsaw, 02-091, Poland.ORCID http://orcid.org/0000-0002-8764-7442
Weronika WoźniakThe Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, 63A Żwirki & Wigury Street, Warsaw, 02-091, Poland.ORCID http://orcid.org/0000-0002-9069-0695
Ernest KucharThe Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, 63A Żwirki & Wigury Street, Warsaw, 02-091, Poland.ORCID http://orcid.org/0000-0002-7883-2427
Henryk SzymańskiThe Department of Pediatrics, St Hedwig of Silesia Hospital, Trzebnica, Poland.ORCID http://orcid.org/0000-0002-0589-7748

Funding

The Nutricia Foundation RG-3/2018
6 · The paper itself

Abstract

Pleuran, as a potent immunomodulator targeting intestinal immunity with a strong safety profile, could be a potential treatment for acute gastroenteritis. This study evaluates the effect of pleuran on the duration and severity of acute infectious diarrhoea in children. This is a multi-centre, randomised, double-blind, placebo-controlled, CONSORT statement superiority trial. Children aged 2-10 years presenting to hospital with acute gastroenteritis were included. The primary outcome measure was the duration of diarrhoea. Twenty-seven children were enrolled. There were no significant differences between the experimental and control groups regarding duration of diarrhoea, hospitalisation, intravenous rehydration and symptom severity. The administration of Pleuran was well tolerated. In this study, Pleuran was ineffective in the treatment of acute gastroenteritis in children. Further studies are needed to investigate its potential as a nutraceutical in children.Clinical registration: ClinicalTrials.gov ID: NCT03988257 (the date of registration: 17/06/2019). The Medical University of Warsaw Bioethical Committee Approval: KB/45/2018. Nutricia Foundation Grant: RG-3/2018.

Indexed as

DiarrheaGastroenteritisAcute DiseaseChildChild, PreschoolDouble-Blind MethodFemaleHumansMaleTreatment OutcomeBeta-glucanInfectious diarrhoeaInnate immunityInterventional trial.Management of acute gastroenteritisMucosal immunity

Identifiers

PMID40374943
PMCPMC12081596

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.