Antibacterial properties of quaternized cellulose nanocrystals in clinical isolates of multidrug-resistant gram-negative bacteria.

Dong Kwon, Nadarajah Vasanthan, Noor Ibrahim, Noel Yahra

Abstract read

In one paragraph

Article in The Journal of antibiotics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dong KwonDepartment of Natural and Life Sciences, Long Island University, Brooklyn, NY, 11201, USA. dong.kwon@liu.edu.

Nadarajah VasanthanDepartment of Natural and Life Sciences, Long Island University, Brooklyn, NY, 11201, USA.

Noor IbrahimDepartment of Natural and Life Sciences, Long Island University, Brooklyn, NY, 11201, USA.

Noel YahraDepartment of Natural and Life Sciences, Long Island University, Brooklyn, NY, 11201, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gram-negative bacterial pathogens are responsible for various infections. Over the past decade, these pathogens have acquired resistance to multiple antibiotics, and the multidrug-resistant (MDR) bacteria have rapidly spread globally, creating significant treatment challenges. Quaternized cellulose nanocrystals (CNCs) have promising antibacterial properties. We previously reported quaternized CNCs with ten-carbon (CNC-3) and sixteen-carbon (CNC-4) alkyl chains and an unmodified CNC (CNC-1). We found that CNC-4 exhibited a significant bactericidal effect against Staphylococcus aureus. In this study, we aim to evaluate the antibacterial properties of the quaternized CNCs against Gram-negative MDR clinical isolates of Acinetobacter baumannii (21 isolates), Klebsiella pneumoniae (18 isolates), and Escherichia coli (7 isolates), including each of their reference species. Agar diffusion, minimum bactericidal concentration (MBC), and bacterial killing pattern were conducted. The results showed that CNC-3 exhibited an MBC of 50 μg ml

Indexed as

Anti-Bacterial AgentsCelluloseDrug Resistance, Multiple, BacterialGram-Negative BacteriaNanoparticlesAcinetobacter baumanniiEscherichia coliGram-Negative Bacterial InfectionsHumansKlebsiella pneumoniaeMicrobial Sensitivity TestsAnti-Bacterial AgentsCellulose

Identifiers

PMID40374922

DOI10.1038/s41429-025-00829-4

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.