Evidence map›Paper›PMID 40374890›Full record

ArticleBritish journal of cancer2025

Assessments of social vulnerability on laryngeal cancer treatment & prognosis in the US.

David J Fei-Zhang, Camaren M Cuenca, Angela D Haskins, Andrew P Stein, David G Lott, Urjeet A Patel, Stephanie S Smith, Amy L Dimachkieh, Nosayaba Osazuwa-Peters, Jill N D'Souza and 3 more

Abstract read
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In one paragraph

Article in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

David J Fei-Zhang *Northwestern University Feinberg School of Medicine, Chicago, IL, USA. david.fei-zhang@northwestern.edu.ORCID http://orcid.org/0000-0002-4485-8274
Camaren M Cuenca *Baylor College of Medicine, Houston, TX, USA.
Angela D HaskinsDepartment of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA.
Andrew P SteinDepartment of Otolaryngology-Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
David G LottDivision of Laryngology, Department of Otolaryngology/Head and Neck Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA.ORCID http://orcid.org/0000-0001-6541-9687
Urjeet A PatelDepartment of Otolaryngology-Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Stephanie S SmithDepartment of Otolaryngology-Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Amy L DimachkiehDepartment of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA.
Nosayaba Osazuwa-PetersDepartment of Head and Neck Surgery & Communication Sciences, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0002-1390-9753
Jill N D'SouzaLouisiana State University Health Sciences Center Department of Otolaryngology and Division of Pediatric Otolaryngology Children's Hospital of New Orleans, New Orleans, LA, USA.
Anthony M SheynDepartment of Pediatric Otolaryngology, Le Bonheur Children's Hospital, Memphis, TN, USA.
Jeffrey C RastatterDepartment of Otolaryngology-Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Daniel C CheliusDepartment of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious social determinants of health (SDoH) studies on laryngeal cancer (LC) have assessed individual factors of socioeconomic status and race/ethnicity but seldom investigate a wider breadth of SDoH-factors for their effects in the real-world. This study aims to delineate how a wider array of SDoH-vulnerabilities interactively associates with LC-disparities.

methodsThis retrospective cohort study assessed 74,495 LC-patients between 1975 and 2017 from the Surveillance-Epidemiology-End Results (SEER) database using the Social Vulnerability Index (SVI) from the CDC, total SDoH-vulnerability from 15 SDoH variables across specific vulnerabilities of socioeconomic status, minority-language status, household composition, and infrastructure/housing and transportation, which were measured across US counties. Univariate linear and logistic regressions were performed on length of care/follow-up and survival, staging, and treatment across SVI scores.

resultsSurvival time dropped significantly by 34.37% (from 72.83 to 47.80 months), and surveillance time decreased by 28.09% (from 80.99 to 58.24 months) with increasing overall social vulnerability, alongside advanced staging (OR 1.15; 95%CI 1.13-1.16), increased chemotherapy (OR 1.13; 95%CI 1.11-1.14), decreased surgical resection (OR 0.91; 95%CI 0.90-0.92), and decreased radiotherapy (OR 0.97; 95%CI 0.96-0.99). DISCUSSION: In this SDoH-study of LCs, detrimental care and prognostic trends were observed with increasing overall SDoH-vulnerability.

Indexed as

Laryngeal NeoplasmsSocial Determinants of HealthSocial VulnerabilityAdultAgedFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesSEER ProgramUnited States

Identifiers

PMID40374890
PMCPMC12304200

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.