Transdifferentiation of Hairy Cell Leukemia to Lytic and Mass-Producing Histiocytic Sarcoma: A Novel Head and Neck Example and Review of the Literature.

Austin J Davies, Parnaz Daneshpajouhnejad, Mugdha Patwardhan, Zaizhen Xu, Darren P Cox

Abstract readCase ReportsReview

In one paragraph

Review in Head and neck pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Austin J DaviesOral and Maxillofacial Surgery, University of the Pacific Arthur A. Dugoni School of Dentistry, San Francisco, CA, USA. adavies@pacific.edu.

Parnaz DaneshpajouhnejadDepartment of Pathology, Stanford Hospital, Palo Alto, USA.

Mugdha PatwardhanOral and Maxillofacial Surgeon, Private Practice California, Huntington Beach, USA.

Zaizhen XuUniversity of the Pacific Arthur A. Dugoni School of Dentistry, San Francisco, USA.

Darren P CoxOral and Maxillofacial Surgery, University of the Pacific Arthur A. Dugoni School of Dentistry, San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTransdifferentiation of hairy cell leukemia to histiocytic sarcoma (HS) has not been previously reported in the head and neck. Given the rarity of HS, it can pose a challenge to diagnose this aggressive malignancy. CASE PRESENTATION: A 93-year-old male with a complex medical history presented with symptomatic and mobile lower anterior teeth. No intraoral growth mass was present initially and radiographic examination showed a radiolucent lesion in the anterior mandible. An incisional biopsy under local anesthesia was performed and histopathologic examination revealed a malignant sarcoma which upon further clinical, immunohistochemical, and molecular workup, confirmed the diagnosis. DIAGNOSIS: Initial histopathologic evaluation of the biopsy rendered a provisional diagnosis of undifferentiated pleomorphic sarcoma. The case was referred to a tertiary care center for complete medical workup and additional ancillary studies where it was definitively diagnosed as a HS. The patient passed away a month after this HS diagnosis.

Indexed as

Cell TransdifferentiationHead and Neck NeoplasmsHistiocytic SarcomaLeukemia, Hairy CellMandibular NeoplasmsAged, 80 and overHumansMaleHairy cell leukemiaHistiocytic sarcomaImmunohistochemistryMolecular pathologyTransdifferentiation

Identifiers

PMID40374868

DOI10.1007/s12105-025-01780-4

PMCPMC12081792

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.