Evidence map›Paper›PMID 40374862›Full record

ArticleArchives of virology2025

Identification of pattern recognition receptors participating in the innate immune response to Tembusu virus.

Jingjing Huang, Xiaoyang Hu, Duo Peng, Qiong Li, Yinuo Song, Dabing Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jingjing HuangNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, People's Republic of China.
Xiaoyang HuNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, People's Republic of China.
Duo PengNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, People's Republic of China.
Qiong LiNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, People's Republic of China.
Yinuo SongNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, People's Republic of China.
Dabing ZhangNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, People's Republic of China. zdb@cau.edu.cn.ORCID http://orcid.org/0000-0003-2658-633X

Funding

China Agriculture Research System of the Ministry of Finance (MOF) and the Ministry of Agriculture and Rural Affairs (MARA) CARS-42-16
6 · The paper itself

Abstract

The pattern recognition receptors (PRRs) participating in the innate immune response to Tembusu virus (TMUV) were investigated using duck embryo fibroblasts (DEFs). TMUV infection induced significant upregulation of RIG-I and MDA5 and strong IFN-α, IFN-β, IL-6, and Mx responses. Overexpression of RIG-I or MDA5 resulted in increased IFN-α, IFN-β, IL-6, and Mx expression and decreased TMUV replication. Conversely, knockdown of RIG-I or MDA5 resulted in decreased IFN-α, IFN-β, IL-6, and Mx expression and increased TMUV replication. These findings demonstrate that RIG-I and MDA5 are essential sensors in the innate immune defense against TMUV, orchestrating cytokine production and restricting viral replication.

Indexed as

FlavivirusFlavivirus InfectionsImmunity, InnateReceptors, Pattern RecognitionAnimalsCytokinesDEAD Box Protein 58DucksFibroblastsInterferon-Induced Helicase, IFIH1Interleukin-6Virus ReplicationCytokinesDEAD Box Protein 58Interferon-Induced Helicase, IFIH1Interleukin-6Receptors, Pattern Recognition

Identifiers

PMID40374862

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.