ArticleMolecular neurobiology2025
Effect of 2 Weeks Naringin Application on Neurological Function and Neurogenesis After Brain Ischemia-Reperfusion in Ovariectomized Rats.
Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Effects of 3',4'-dihydroxyflavonol treatment on Neu N and BDNF and ICAM levels in the striatum of rats subjected to transient bilateral carotid occlusion-induced ischemia-reperfusion.Journal of bioenergetics and biomembranes · 2026Article
- Preventive Effect of Gallic Acid-Loaded Carrageenan Nanoparticles Against Cerebral Ischemia/Reperfusion Injury in Rat: Modulation of Oxidative Pathway.Food science & nutrition · 2026Article
- Microbe-driven flavonoid biotransformation revealed by multi-omics analysis during Hua Feng Dan Yao Mu fermentation.Frontiers in microbiology · 2026Article
- Aging Rewires Neuronal Metabolism, Exacerbating Cell Death After Ischemic Stroke: A Hidden Reason for the Failure of Neuroprotection.International journal of molecular sciences · 2025Article
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7 authors.
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Abstract
Cerebral ischemia-reperfusion (I/R) is a condition that occurs when blood flow is restored after a temporary interruption and may lead to deterioration in brain functions depending on the time passed. One of the changes in functions is neurological score values. This study aimed to determine the effect of brain ischemia reperfusion and 2-week naringin supplementation on changes in neurological score and neurogenesis in ovariectomized female rats. Experimental groups of 36 Wistar-albino-type female rats were created as follows: control group: no anesthesia or surgical procedure was applied. Ovariectomy-sham brain I/R group: After the ovariectomy was performed under general anesthesia, the carotid artery regions were opened and closed, and sham ischemia-reperfusion was performed, followed by a vehicle application for 2 weeks (2 weeks, 1 ml 0.25% carboxymethylcellulose). Ovariectomy-I/R group: After ovariectomy, carotid arteries were isolated under general anesthesia, ligated for 30 min, and reperfused for 2 weeks after ischemia was performed. Ovariectomy-I/R sham treatment group: After ovariectomy, the carotid arteries were isolated under general anesthesia, then ligated and ischemia was performed for 30 min, and then reperfusion and vehicle application were performed for 2 weeks. Ovariectomy-I/R naringin treatment group: After ovariectomy, carotid arteries were isolated under general anesthesia, ligated for 30 min, and ischemia was performed, followed by naringin application with reperfusion for 2 weeks. Neurological scoring values performed on the 1st, 7th, and 14th days after the surgical procedure significantly increased with ischemia-reperfusion. Also, hippocampus and frontal cortex calbindin, alpha/beta-tubulin, and Neu-N levels were reduced considerably by ischemia-reperfusion. However, it was observed that a 2-week naringin application significantly suppressed the increase in neurological scores. The suppression in neurological score values became more evident in the 2nd week. Our results show that the impairment of motor functions and neurogenesis in the frontal cortex and hippocampus in brain ischemia-reperfusion after ovariectomy in female rats was significantly improved by 2 weeks of naringin supplementation.
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