Evidence map›Paper›PMID 40374836›Full record

ArticleScientific reports2025

Modulation of HER2 internalization enhances single-dose antibody-drug potency in HER2

Abbey Zidel, Alex Benton, Emma Brown, Shayla Shmuel, Alex Vanover, Sandeep Surendra Panikar, Ron Bose, Haeseong Park, Andrew A Davis, Patrícia M R Pereira

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abbey Zidel *Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Alex Benton *Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Emma BrownDepartment of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Shayla ShmuelDepartment of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Alex VanoverDepartment of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Sandeep Surendra PanikarDepartment of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Ron BoseWashington University School of Medicine, 4515 McKinley Avenue, Campus Box 8069, St. Louis, MO, USA.
Haeseong ParkGastrointestinal Cancer Center, Center for Cancer Therapeutic Innovation, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Andrew A DavisDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Patrícia M R PereiraDepartment of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA. ribeiropereirap@wustl.edu.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Improving radiolabeled imaging and targeting of HER2 positive EG cancers using lovastatinR01CA244233 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JANJIGIAN, YELENA Y, LEWIS, JASON S. · 2021 to 2025
$3.4M
Reversing Drug Resistance in Tumors with Clickable Antibody PairsR37CA276498 · NCI · WASHINGTON UNIVERSITY · PI Patricia Manuela Ribeiro Pereira · 2023 to 2026
$2.5M
ACQUISITION OF A PRE-CLINICAL SIMULTANEOUS PET/MR SCANNERS10OD018515 · OD · WASHINGTON UNIVERSITY · PI LAFOREST, RICHARD ANDRE · 2016 to 2016
$1.9M
Acquisition of high-resolution PET/CT preclinical imaging instrument at MIRS10OD030403 · OD · WASHINGTON UNIVERSITY · PI SHOGHI, KOORESH ISAAC · 2021 to 2021
$929k
American Cancer Society IRG-21-133-64-03National Cancer Center R37CA276498National Cancer Center,United States R01 CA244233-01A1NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA244233NCI NIH HHS R37 CA276498NIH HHS S10 OD018515NIH HHS S10 OD030403
6 · The paper itself

Abstract

HER2 is a membrane receptor tyrosine kinase overexpressed in 18-20% of gastric tumors. Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) that targets HER2-positive (HER2

Indexed as

Erb-b2 Receptor Tyrosine KinasesStomach NeoplasmsAdo-Trastuzumab EmtansineAnimalsCell Line, TumorFemaleHumansMaleMicePositron Emission Tomography Computed TomographyQuinolinesTrastuzumabXenograft Model Antitumor AssaysAdo-Trastuzumab EmtansineERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesneratinibQuinolinesTrastuzumabHER2ImmunoPETNeratinibStatinT-DM1

Identifiers

PMID40374836
PMCPMC12081668

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.