Observational studyScientific reports2025
Association of eosinophil major basic protein with intraocular lens dislocation in atopic dermatitis.
Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Lens epithelial cell damage and reduced aquaporin-1 immunoreactivity in liquefied mature cataracts.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Lens capsular accumulation of advanced glycation end products in eyes with intraocular lens dislocation.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Early-onset dead bag syndrome following cataract surgery: a case report with clinical and histopathological findings.BMC ophthalmology · 2026Article
- Probiotic lactic acid bacterial strains MG4693 and MG5474 alleviate atopic dermatitis by enhancing intestinal barrier integrity and modulating the immune system.Food & nutrition research · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study aimed to investigate whether eosinophil major basic protein (MBP), which is linked to cataract formation due to lens epithelial cell (LEC) damage in atopic dermatitis (AD), is associated with intraocular lens (IOL) dislocation. This retrospective observational study was conducted at a Medical University Hospital and included 22 eyes (10 AD, 12 non-AD [NAD]) that underwent IOL explantation and fixation. Surgeries were conducted to extract the intraocular lens capsule for morphological evaluations. Quantitative analysis of the MBP staining was conducted using the staining area ratio (SAR) gap. MBP staining was negative in all cases for both the lens capsule and LEC. The SAR gap in Soemmering's ring was significantly higher in the AD group (14.3 ± 8.7%) than in the NAD group (1.1 ± 1.1%) (p = 0.0037). In contrast, the SAR gap for fibrous metaplasia showed no significant difference between the AD (8.3 ± 13.2%) and NAD (6.5 ± 12.3%) groups (p = 0.75). Six cases of fibrous metaplasia, including those in the NAD group, showed SAR gaps equal to or greater than those in the positive control group, with five classified as low-density fibrosis (LDF). While Soemmering's rings in AD cases demonstrated greater MBP immunoreactivity than NAD controls, both groups exhibited MBP-positive fibrous metaplasia specimens.
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Registered trials
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