ArticleScientific reports2025
Electrochemical surface plasmon resonance based biosensor for α-fetoprotein detection via different coupling strategies.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Early cancer biomarker detection using a prism-based multi-resonant Ag/BaTiO₃/BP plasmonic sensor.Scientific reports · 2026Article
- Molecular states and interfacial interactions at solid-liquid interfaces: advances and challenges in multimodal characterization.Beilstein journal of nanotechnology · 2026Review
- Tungsten Oxide-Mediated Photocatalytic Silver Enhancement in a QCM Immunosensor for Alpha-Fetoprotein Detection.Biosensors · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrochemical surface plasmon resonance (ESPR) based biosensors play significant role in cancer detection due to its ability for real-time analysis and rapid detection. Herein, ESPR based biosensor was designed employing three different coupling strategies for the detection of cancer biomarker α-fetoprotein (AFP), a liver cancer biomarker. AFP antibody was immobilized on gold coated glass sensor disk using three different coupling strategies viz. (i) 1-Ethyl-3-[3-dimethylaminopropyl] carbodiimide / N-hydroxy succinamide (EDC/NHS), (ii) ethylene diamine/ glutaraldehyde (EDA/GA) and (iii) polyaniline/glutaraldehyde (PANI/GA) strategies. Among the three coupling strategies, immobilization via EDA/GA strategy afforded highest sensitivity (28°/(ng/ml)) with reasonable linear range (0.5-3 ng/ml) and whereas EDC/NHS strategy afforded wide linear range (5-70 ng/ml) with reasonable sensitivity (2.12°/(ng/ml). Immobilization efficiency and interaction steps involved in the sensor construction were investigated by electrochemical impedance spectroscopy. The sensor constructed using EDC/NHS strategy was validated by quantifying AFP in human blood serum samples, where the results are consistent with the values determined using ELISA. This fundamental study can help the researcher to choose the relevant coupling strategy for achieving desired sensor characteristics in clinical analysis of cancer biomarkers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.