Evidence map›Paper›PMID 40374749›Full record

ArticleScientific reports2025

Chronic rejection models for vascularized composite tissue allotransplantation.

Daniel T Fisher, Emily Mackey, Eugene Kononov, Paul N Bogner, Umesh Sharma, Han Yu, Curtis L Cetrulo, Mukund Seshadri, Pawel Kalinski, Joseph J Skitzki and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Chronic Rejection in Facial Vascularized Composite Allotransplantation (fVCA).Results and problems in cell differentiation · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daniel T FisherDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Emily MackeyComparative Oncology Shared Resource, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Eugene KononovDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Paul N BognerDepartment of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Umesh SharmaDepartment of Medicine, Division of Cardiology, University at Buffalo, Buffalo, NY, USA.
Han YuDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Curtis L CetruloDepartment of Surgery, Division of Plastic Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Mukund SeshadriDepartment of Oral Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Pawel KalinskiDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Joseph J SkitzkiDepartment of General Surgery, Cleveland Clinic, Cleveland, OH, USA.
Elizabeth A RepaskyDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Minhyung KimDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. Minhyung.Kim@RoswellPark.org.

Funding

U.S. Department of Defense HT9425-23-1-0529
6 · The paper itself

Abstract

Vascularized composite tissue allotransplantation (VCA) has transformed patients' lives by enabling limb, face, abdominal wall, and penile transplants. Despite advancements in screening and immunosuppression, chronic rejection continues to limit the success of VCA. Lack of reliable preclinical models exacerbates this challenge. Here, we report on new mouse models of chronic rejection following heterotopic hind limb VCA. We employed different levels of MHC mismatch using CD8 knockout C57BL/6 mice as recipients along with BALB/c or B6 H2-Ab1

Indexed as

Composite Tissue AllograftsGraft RejectionVascularized Composite AllotransplantationAnimalsChronic DiseaseDisease Models, AnimalMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, Knockout

Identifiers

PMID40374749
PMCPMC12081738

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.