ArticleScientific reports2025
Low expression of miR-7-5p promotes resistance to radiotherapy in lung cancer through direct upregulation of PKP2 expression.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- A two-gene prognostic model for lung adenocarcinoma using summary-data-based Mendelian randomization analysis and Cox proportional hazards regression.Future science OA · 2026Article
- Article
- Evaluating Potential Therapeutic Targets and Drug Repurposing Based on the Esophageal Cancer Subtypes.Pharmaceuticals (Basel, Switzerland) · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Lung cancer remains a significant global health challenge, with advanced stages often limiting surgical options and necessitating systemic therapies, such as radiotherapy. Resistance to radiotherapy frequently undermines the treatment efficacy. This study explored the role of miR-7-5p in modulating the expression and radiosensitivity of plakophilin-2 (PKP2) in non-small cell lung cancer (NSCLC). Using clonogenic assays, CCK-8 assays, immunofluorescence staining, western blotting, and reporter gene assays, we assessed the effects of miR-7-5p overexpression and inhibition on A549 NSCLC cells. The results show that miR-7-5p overexpression enhanced radiosensitivity by increasing DNA damage (evidenced by higher γ-H2AX foci) and inhibiting non-homologous end joining (NHEJ) repair. Bioinformatic and experimental validation identified PKP2 as a direct target of miR-7-5p. PKP2 overexpression mitigated the radiosensitizing effects of miR-7-5p, confirming the miR-7-5p/PKP2 axis's role in regulating radiosensitivity. This study highlights the potential of targeting the miR-7-5p/PKP2 pathway to overcome radiotherapy resistance in NSCLC and offers a promising therapeutic approach to enhance treatment outcomes.
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