ArticleScientific reports2025
Structural and functional thalamic alterations in major depressive disorder with comorbid chronic pain.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The efficacy of acupuncture for depression-associated chronic pain: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Article
- Intelligent diagnosis of major depressive disorder with edge convolution and contrastive learning.PloS one · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
Major Depressive Disorder (MDD) is a prevalent mental health condition, often accompanied by chronic pain. This study investigates the structural and functional characteristics of the thalamus in individuals with MDD, both with and without comorbid pain, using magnetic resonance imaging (MRI) techniques. A total of 165 participants, including healthy controls, individuals with MDD, and those with comorbid depression and pain, were enrolled. The study found a reduction of the left thalamus in the MDD group, while no significant differences in thalamic volume were observed in the right thalamus or in the depression and pain comorbidity group. Functionally, no significant differences in fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo) were found between groups. However, correlation analysis revealed associations between thalamic structure and cognitive performance, as well as clinical symptom severity in the depression and pain comorbidity group. These findings highlight the thalamus's role in the pathophysiology of MDD and its interaction with chronic pain, suggesting potential targets for diagnostic and therapeutic strategies.
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