Evidence map›Paper›PMID 40374620›Full record

ReviewHuman vaccines & immunotherapeutics2025

Pneumococcal vaccine hyporesponsiveness in people living with HIV: A narrative review of immunological mechanisms and insights from minimally invasive lymph node sampling.

Giovanni E Loe-Sack-Sioe, Danny W de Vos, Leo G Visser, Simon P Jochems, Anna H E Roukens

Abstract readReview
In one paragraph

Review in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Giovanni E Loe-Sack-SioeCenter for Infectious Diseases, Subdepartment of Research, Leiden University, Leiden, The Netherlands.ORCID 0009-0006-1489-6962
Danny W de VosCenter for Infectious Diseases, Subdepartment of Infectious Diseases, Leiden University, Leiden, The Netherlands.
Leo G VisserCenter for Infectious Diseases, Subdepartment of Infectious Diseases, Leiden University, Leiden, The Netherlands.
Simon P JochemsCenter for Infectious Diseases, Subdepartment of Research, Leiden University, Leiden, The Netherlands.
Anna H E RoukensCenter for Infectious Diseases, Subdepartment of Infectious Diseases, Leiden University, Leiden, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite highly effective antiretroviral therapy, people living with HIV (PLWH) remain at elevated risk for invasive pneumococcal disease. Clinical studies show that, even with high CD4

Indexed as

HIV InfectionsLymph NodesPneumococcal InfectionsPneumococcal VaccinesAntibodies, BacterialGerminal CenterHumansAntibodies, BacterialPneumococcal Vaccinesgerminal centerslymph node fine-needle aspirationpeople living with HIVpneumococcal conjugate vaccinepneumococcal polysaccharide vaccinePneumococcal vaccination

Identifiers

PMID40374620
PMCPMC12087491

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.