Evidence map›Paper›PMID 40374596›Full record

ArticleNature communications2025

Gabapentinoids confer survival benefit in human glioblastoma.

Joshua D Bernstock, Mulki Mehari, Jakob V E Gerstl, David M Meredith, Pablo A Valdes, Philip Heesen, Vardhaan S Ambati, Saritha Krishna, Jason A Chen, Harshit Arora and 28 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Review
  3. Gabapentin and cognitive impairment after traumatic brain injury: A multinational cohort of 49,925 patients.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
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  10. Review
  11. Review
  12. Review
  13. Article
  14. Cenobamate reduces epileptiform activity in theFrontiers in neuroscience · 2025
    Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Joshua D Bernstock *Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. jbernstock@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-7814-3867
Mulki Mehari *Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Jakob V E Gerstl *Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
David M MeredithDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Pablo A ValdesDepartment of Neurosurgery, University of Texas Medical Branch, Galveston, TX, USA.
Philip HeesenComputational Neuroscience Outcomes Center (CNOC), Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Vardhaan S AmbatiDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0074-9217
Saritha KrishnaDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Jason A ChenDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Harshit AroraDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Benjamin R JohnstonDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6456-3908
Mikias NegussieDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6060-6926
Kristina GriecoDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Cesar Nava GonzalesDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Abraham DadaDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-2125-7011
Anna B Lebouille-VeldmanDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Aymen KabirDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Lennard SpanehlDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0009-9419-7302
Jasleen KaurDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Sena OtenDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Youssef E SibihDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-0839-5428
Rania A MekaryComputational Neuroscience Outcomes Center (CNOC), Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1636-0759
Andy DanielDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
John Frederick de GrootDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1454-6461
Saef IzzyDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2822-6736
Florian A GesslerDepartment of Neurosurgery, Rostock University Medical Center, Rostock, Germany.
Scellig StoneDepartment of Neurosurgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4546-6790
Omar ArnaoutDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Yi LuDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8180-8578
Bryan D ChoiDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Matthew D HallDepartment of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL, USA.
Minesh P MehtaHerbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.ORCID http://orcid.org/0000-0002-4812-5713
Yazmin OdiaDepartment of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL, USA.ORCID http://orcid.org/0000-0003-3602-3899
Gregory K FriedmanDivision of Pediatrics, Neuro-Oncology Section, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-6653-7420
E A ChioccaDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5183-1670
Pier Paolo PeruzziDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5034-2963
Timothy R SmithDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Shawn L Hervey-JumperWeill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA. shawn.hervey-jumper@ucsf.edu.ORCID http://orcid.org/0000-0003-4699-260X

Funding

Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang · 2002 to 2026
$57.4M
Cortical information loss in diffuse low-grade glioma infiltrated cortexR01NS137950 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Shawn L. Hervey-Jumper · 2024 to 2026
$1.2M
NCI NIH HHS P50 CA097257NINDS NIH HHS R01 NS137950
6 · The paper itself

Abstract

Neuronal-glioma interactions are increasingly recognized as critical in the development and progression of central nervous system tumors. Recent research highlights that gliomas can integrate into neural circuits through various mechanisms, including the synaptogenic factor thrombospondin-1 (TSP-1). This new mechanistic understanding of cancer neuroscience allows for novel insights into target discovery. Critically, therapies that modulate neuron-tumor interactions remain agnostic to other oncogenic changes within tumor cells yet may still target fundamental drivers of tumor growth. In line with these findings and controlling for critical confounding variables, we demonstrate a survival benefit associated with gabapentin (an antagonist of TSP-1) following surgical resection of newly diagnosed glioblastoma. This retrospective, multi-institutional cohort study included 1,072 patients, with a discovery cohort of 693 patients and an additional 379 patients from a separate site for external validation. Furthermore, our findings indicate that gabapentin administration is associated with reduced serum TSP-1 levels, suggesting its potential as a future biomarker.

Indexed as

Brain NeoplasmsGabapentinGlioblastomaAdultAgedBiomarkers, TumorFemaleHumansMaleMiddle AgedRetrospective StudiesThrombospondin 1Biomarkers, TumorGabapentinThrombospondin 1

Identifiers

PMID40374596
PMCPMC12081740

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.