Evidence map›Paper›PMID 40374588›Full record

ArticleBJU international2025

What is lost in an average? Identifying distinct post-radical prostatectomy functional recovery profiles.

Patrick Lewicki, Kevin Ginsburg, Nnenaya Mmonu, Corinne Labardee, Anna Johnson, James Peabody, Adam Gadzinski, Alice Semerjian, Tudor Borza, Brian R Lane and 2 more

Abstract read
In one paragraph

Article in BJU international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Patrick LewickiDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.ORCID https://orcid.org/0000-0002-0692-2909
Kevin GinsburgDepartment of Urology, Wayne State University, Detroit, MI, USA.ORCID https://orcid.org/0000-0002-8140-9793
Nnenaya MmonuDepartment of Urology, NYU Langone Medical Center, New York, NY, USA.
Corinne LabardeeDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.
Anna JohnsonDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.
James PeabodyHenry Ford Health System, Detroit, MI, USA.
Adam GadzinskiComprehensive Urology, Beaumont Hospital, Royal Oak, MI, USA.
Alice SemerjianDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.
Tudor BorzaDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.
Brian R LaneSpectrum Health Hospital System, Grand Rapids, MI, USA.
Andrew E KrummDepartment of Learning Health Sciences, University of Michigan, Ann Arbor, MI, USA.ORCID https://orcid.org/0000-0001-9714-1632
Michigan Urological Surgery Improvement Collaborative

Funding

Tissue/InformaticsP50CA186786 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ganesh S Palapattu · 2014 to 2026
$27.6M
Advanced Training in Urologic OncologyT32CA180984 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ganesh S Palapattu, VAHAKN B SHAHINIAN · 2014 to 2026
$3.4M
NCI NIH HHS P50 CA186786NCI NIH HHS T32 CA180984
6 · The paper itself

Abstract

objectiveTo describe, via latent variable mixture modelling, distinct post-radical prostatectomy (RP) patient-reported outcome (PRO) recovery profiles, which are positioned to complement currently disseminated statistical averages for shared decision-making. PATIENTS AND

methodsPatients undergoing RP and completing the 26-item Expanded Prostate Cancer Index Composite 12 months after surgery were identified from the Michigan Urological Surgery Improvement Collaborative data registry. Hierarchical cluster analysis and latent variable mixture modelling was applied to urinary incontinence (UI) and sexual function (SF) recovery scores, and final models chosen based on optimal performance.

resultsA total of 3956 patients comprised the study cohort. Three distinct UI profiles were identified with prevalence of 49%, 37% and 14% from best to worst recovery, respectively. Four distinct SF profiles were identified with prevalence of 14%, 24%, 42%, and 20%, from best to worst recovery, respectively. The last two SF profiles had similar function scores but differed based on perception of function being bothersome. Limitations include incomplete PRO capture, which may introduce bias.

conclusionsWe identify distinct UI and SF recovery profiles and their prevalence from a large, prospectively maintained registry, potentially improving interpretability of PRO data for decision making.

Indexed as

Patient Reported Outcome MeasuresProstatectomyProstatic NeoplasmsRecovery of FunctionUrinary IncontinenceAgedHumansMaleMiddle Agedfunctional outcomesfunctional recoverylocalised prostate cancerpatient‐reported outcomespost‐prostatectomy sexual dysfunctionpost‐prostatectomy urinary incontinenceradical prostatectomy

Identifiers

PMID40374588
PMCPMC12442113

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.