Evidence map›Paper›PMID 40374400›Full record

Trial reportBritish journal of anaesthesia2025

Multimodal prehabilitation before lung resection surgery: a multicentre randomised controlled trial.

Kristian Brat, Milan Sova, Pavel Homolka, Marek Plutinsky, Samuel Genzor, Alena Pokorna, Filip Dosbaba, Barbora Imrichova, Zdenek Chovanec, Ladislav Mitas and 5 more

2 registry-linked trialsAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04826575 nacompletednot on this map

High Intensity Respiratory Muscle Training as a Pre-habilitation in Lung Surgery

TypeinterventionalSponsorSt. Anne's University Hospital Brno, Czech RepublicRan2021 to 2024Enrolled150ConditionsLung Cancer, Post-Op ComplicationArmsHigh intensity inspiratory and expiratory muscle training
NCT07691944 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of VExUS Score-Guided Intraoperative Goal-Directed Fluid Therapy on Postoperative Pulmonary Complications in Elderly Patients Undergoing McKeown Minimally Invasive Esophagectomy: A Randomized Controlled Trial

TypeobservationalSponsorFirst Affiliated Hospital of Chongqing Medical UniversityRan2026 to 2026Enrolled126ConditionsEsophageal Cancer (EsC), Postoperative Pulmonary Complications (PPCs)ArmsVExUS Score-Guided Intraoperative Goal-Directed Fluid Therapy
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. The prehabilitation paradox in ventral hernia: from universal to personalized care.Hernia : the journal of hernias and abdominal wall surgery · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Kristian BratDepartment of Respiratory Diseases, University Hospital Brno, Brno, Czech Republic; Faculty of Medicine, Masaryk University, Brno, Czech Republic; Center for Pulmonology and Interventional Bronchology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Milan SovaDepartment of Pulmonary Diseases and Tuberculosis, University Hospital Olomouc, Olomouc, Czech Republic; Faculty of Medicine, Palacky University Olomouc, Olomouc, Czech Republic.
Pavel HomolkaFaculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Sports Medicine and Rehabilitation, St. Anne's University Hospital Brno, Brno, Czech Republic.
Marek PlutinskyDepartment of Respiratory Diseases, University Hospital Brno, Brno, Czech Republic; Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Samuel GenzorDepartment of Pulmonary Diseases and Tuberculosis, University Hospital Olomouc, Olomouc, Czech Republic; Faculty of Medicine, Palacky University Olomouc, Olomouc, Czech Republic.
Alena PokornaFaculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Sports Medicine and Rehabilitation, St. Anne's University Hospital Brno, Brno, Czech Republic.
Filip DosbabaFaculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Rehabilitation, University Hospital Brno, Brno, Czech Republic.
Barbora ImrichovaFaculty of Medicine, Palacky University Olomouc, Olomouc, Czech Republic; Department of Sports Medicine and Cardiovascular Rehabilitation, University Hospital Olomouc, Olomouc, Czech Republic.
Zdenek ChovanecFaculty of Medicine, Masaryk University, Brno, Czech Republic; First Department of Surgery, St. Anne's University Hospital Brno, Brno, Czech Republic.
Ladislav MitasFaculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Surgery, University Hospital Brno, Brno, Czech Republic.
Monika MikulaskovaFaculty of Medicine, Palacky University Olomouc, Olomouc, Czech Republic; Department of Sports Medicine and Cardiovascular Rehabilitation, University Hospital Olomouc, Olomouc, Czech Republic.
Michal SvobodaFaculty of Medicine, Masaryk University, Brno, Czech Republic; Institute of Biostatistics and Analyses, Ltd., Brno, Czech Republic.
Lyle OlsonDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Ivan CundrleFaculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Anesthesiology and Intensive Care, St. Anne's University Hospital Brno, Brno, Czech Republic. Electronic address: Ivan.Cundrle@seznam.cz.
study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRespiratory muscle training may improve ventilatory efficiency (V

methodsWe conducted a prospective multicentre, randomised controlled trial (NCT04826575) to examine the effect of prehabilitation in individuals undergoing lung resection. Participants were defined as high-risk for postoperative pulmonary complications if they achieved V

resultsA total of 122 patients (46% female; age range: 64-75 yr) completed the study. Postoperative pulmonary complications occurred in 20/58 (34%) of patients randomised to multimodal prehabilitation, compared with 35/64 (55%) patients receiving usual care (odds ratio 2.29 [95% confidence interval 1.10-4.77]; P=0.029). Hospital length of stay was shorter after multimodal rehabilitation compared with patients randomised to receive usual care (from 9 [7-11] days to 7 [6-9] days; P=0.038). After prehabilitation, mean (sd) V

conclusionsIn high-risk patients undergoing elective lung resection surgery, multimodal prehabilitation, including high-intensity respiratory muscle training to target V

Indexed as

Breathing ExercisesLung DiseasesPneumonectomyPostoperative ComplicationsPreoperative CarePreoperative ExerciseAgedCombined Modality TherapyFemaleHumansLength of StayMaleMiddle AgedProspective StudiesSmoking Cessationcardiopulmonary exercise testinglung resection surgerypostoperative complicationsprehabilitationventilatory efficiency

Identifiers

PMID40374400
PMCPMC12597589

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.