ArticleBMJ paediatrics open2025
Global analysis of tetanus incidence and mortality in children under 5 years: findings from the Global Burden of Disease Study 2021.
Article in BMJ paediatrics open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Structural asymmetry in knowledge of active and passive tetanus immunization among frontline healthcare workers: Implications for adult booster policy in China.Human vaccines & immunotherapeutics · 2026Article
- Intrathecal Human Tetanus Immunoglobulin for Post-Neonatal Tetanus in Resource-Limited Settings: An Old Idea with New Evidence.The American journal of tropical medicine and hygiene · 2026Article
- Rare Survival of a 9-Year-Old Boy Managed for Post-Neonatal Tetanus Without Intensive Care at Soroti Regional Referral Hospital, Uganda: A Case Report.International medical case reports journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnderstanding trends in the incidence and mortality of tetanus in infants and young children is essential to develop prevention and intervention strategies.
methodsData on tetanus incidence and mortality among children aged under 5 years from 1990 to 2021 were obtained from the Global Burden of Disease Study 2021. Estimated annual percentage changes were calculated to assess the trends in the change of children's tetanus incidence and mortality and the burden of disease. The relationship between disease burden and Sociodemographic Index (SDI) was also analysed.
resultsGlobally, the incidence of children's tetanus decreased from 308 931 cases in 1990 to 17 788 cases in 2021. Similarly, tetanus mortality among children has decreased significantly over the past 30 years, from 24.62 per 100 000 to 1.34 per 100 000, with little gender difference observed. The highest rates were seen in the Caribbean, Central Sub-Saharan Africa, Eastern Sub-Saharan Africa, North Africa and the Middle East, South Asia, Southeast Asia and Western Sub-Saharan Africa. The incidence and mortality of tetanus in children are significantly different in areas with different SDI levels. The incidence and mortality in areas with low SDI are higher than those in areas with high SDI.
conclusionThe incidence and mortality of tetanus in children have decreased to varying degrees worldwide, but they are still high in some regions, especially in countries with low SDI, which highlights the impact of socioeconomic factors on the outcome of the disease. More targeted supportive measures are imperative for mitigating the global burden posed by children's tetanus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.