ArticleOpen heart2025
Ratio of interventricular septal thickness to global longitudinal strain accurately identifies cardiac amyloidosis.
Article in Open heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- LVH-Voltage Discordance and Myocardial Dysfunction in Wild-Type Transthyretin Cardiomyopathy: A Prospective Cohort Study.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Imaging Advances in Light Chain Amyloidosis.Diagnostics (Basel, Switzerland) · 2026Review
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesConventional transthoracic echocardiographic measurements like global longitudinal strain (GLS) have shown promise in distinguishing cardiac amyloidosis (CA), but with limited specificity. We investigated the performance of common echo measurements, GLS, and their combinations in discriminating CA from an undifferentiated cohort with increased left ventricular wall thickness.
methodsWe conducted a retrospective single-centre case-control study of 876 echos from 232 patients with CA and 1325 echos from 279 patients who underwent pyrophosphate scintigraphy but had CA definitively ruled out. Common echo measurements were collected and additional GLS measurements were performed post hoc. We reported discrimination performance with the area under the receiver operating characteristic curve (AUC) and associated sensitivity, specificity and positive predictive value at the optimal threshold.
resultsWe found that the ratio of end-diastolic interventricular septal thickness (IVSd) to GLS had the highest performance in differentiating CA with an AUC of 0.812. At the optimal threshold of >0.15, IVSd/GLS had a sensitivity of 0.70 and specificity of 0.80 for CA. Other measurements and ratios, including the ratio of left ventricular ejection fraction to GLS (AUC 0.682), had lower performance when evaluated against a suspicious control cohort with increased left ventricular wall thickness.
conclusionIf validated in prospective multi-centre studies, the routine measurement of IVSd/GLS can assist with earlier diagnosis of CA, resulting in earlier initiation of treatment in this underserved population.
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