Evidence map›Paper›PMID 40374198›Full record

ArticleBMJ case reports2025

Managing bipolar affective disorder in chronic kidney disease when lithium is no longer an option.

Kate Corrigan, Darragh Larkin, Margaret Gallagher, Allys Guerandel

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kate CorriganKildare/West Wicklow Mental Health Services, Naas General Hospital, Kildare, Ireland kathryna.corrigan@hse.ie.ORCID http://orcid.org/0000-0001-5407-0408
Darragh LarkinSt Vincent's University Hospital, Dublin, Ireland.
Margaret GallagherSt Vincent's University Hospital, Dublin, Ireland.
Allys GuerandelUniversity College Dublin, Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The therapeutic benefits of lithium use in bipolar affective disorder (BPAD) are well established; however, it can cause adverse side effects including chronic kidney disease and progression to end-stage renal disease (ESRD). We describe the cases of two patients with BPAD stable on lithium for many years. In both cases, kidney function declined towards ESRD, prompting cessation of lithium therapy and precipitating a period of mental instability. Concurrent lithium and haemodialysis treatment was successfully trialled in case 2. There is a dearth of guidance on managing those on lithium therapy with kidney disease progressing towards ESRD. We describe the management and outcomes of two such patients attending a community mental health team.

Indexed as

Antimanic AgentsBipolar DisorderKidney Failure, ChronicLithium CompoundsRenal Insufficiency, ChronicDisease ProgressionHumansRenal DialysisAntimanic AgentsLithium CompoundsBipolar I disorderChronic renal failureDrugs: psychiatry

Identifiers

PMID40374198
PMCPMC12083063

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.