Evidence map›Paper›PMID 40374190›Full record

Trial reportBMJ open gastroenterology2025

Akita Japan population-based colonoscopy screening trial: report of initial colonoscopy.

Shin-Ei Kudo, Noriaki Takahashi, Kenta Kodama, Fumio Ishida, Hiro-O Yamano, Seiichiro Yamamoto, Koichi Nagata, Kunihiko Wakamura, Hiro-O Matsushita, Nobuo Hiwatashi and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shin-Ei KudoDigestive Disease Center, Showa Medical University Northern Yokohama Hospital, Yokohama, Japan.
Noriaki TakahashiNational Cancer Center Institute for Cancer Control, Tokyo, Japan.
Kenta KodamaDigestive Disease Center, Showa Medical University Northern Yokohama Hospital, Yokohama, Japan.
Fumio IshidaDigestive Disease Center, Showa Medical University Northern Yokohama Hospital, Yokohama, Japan.
Hiro-O YamanoDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Seiichiro YamamotoShizuoka Graduate University of Public Health, Shizuoka, Japan.
Koichi NagataCancer Screening Center, National Cancer Center Hospital, Tokyo, Japan.
Kunihiko WakamuraDigestive Disease Center, Showa Medical University Northern Yokohama Hospital, Yokohama, Japan.
Hiro-O MatsushitaDigestive Disease Center, Akita Red Cross Hospital, Akita, Japan.
Nobuo HiwatashiHirose Hospital, Sendai, Japan.
Takahisa MatsudaCancer Screening Center, National Cancer Center Hospital, Tokyo, Japan takahisa.matsuda@med.toho-u.ac.jp.ORCID http://orcid.org/0000-0002-9244-2820
Hiroshi SaitoNational Cancer Center Institute for Cancer Control, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the safety and quality of baseline screening colonoscopy in a randomised controlled trial (RCT).

methodsA population-based RCT with an explanatory design is ongoing to evaluate the efficacy of colonoscopy screening in 9751 men and women aged 40-74 years at average risk of colorectal cancer (CRC) in Japan. Screening colonoscopies for the intervention group were performed from June 2009 to June 2017.

resultsOf the 4861 participants in the intervention group, 4495 (92.5%) underwent screening colonoscopy. The quality of bowel preparation was excellent (34.8%) or good (45.6%) in 80.4% of cases. The caecal intubation rate was 99.7% (4483/4495), and the mean (±SD) withdrawal time was 9.7 (±5.3) min. The adenoma detection rate (ADR) was 39.4% (1770/4495). A total of 27 participants (0.6%) were diagnosed with CRC, and 266 (5.9%) were diagnosed with advanced neoplasia (AN). In women, adenomas were more frequently detected in the proximal colon than in the distal colon (proximal: 18.9% vs distal: 16.4%, p=0.024), and a similar trend was observed for AN (proximal: 2.4% vs distal: 1.5%, p=0.045). No serious adverse events related to screening colonoscopy were reported, and minor adverse events were observed in two participants (0.04%).

conclusionsAdequate performance in compliance, ADR, and safety was confirmed in the intervention arm of the RCT evaluating the efficacy of screening colonoscopy. The high quality of screening colonoscopy observed in the trial suggests its feasibility as a population-based screening approach. TRIAL REGISTRATION NUMBER: UMIN000001980.

Indexed as

AdenomaColonoscopyColorectal NeoplasmsEarly Detection of CancerMass ScreeningAdultAgedFemaleHumansJapanMaleMiddle AgedCOLONOSCOPYCOLORECTAL CANCERCOLORECTAL CANCER SCREENING

Identifiers

PMID40374190
PMCPMC12083350

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.