ArticleBrain stimulation
Theta-frequency subthalamic nucleus stimulation increases decision threshold.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Cognitive trajectories in Parkinson's disease patients, a review on the impact of subthalamic deep brain stimulation (STN-DBS) and emerging adaptive strategies.Translational psychiatry · 2026Review
- From symptom-based heterogeneity to mechanism-based profiling in youth ADHD: the promise of computational psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Real-time Bayesian optimization of deep brain stimulation for personalized cognitive control enhancement.bioRxiv : the preprint server for biology · 2025Article
- 20 Hz beta stimulation of the subthalamic nucleus improves response inhibition in Parkinson's disease.Brain communications · 2025Article
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Authors and funding
9 authors.
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Abstract
introductionExecutive functions are often impaired in patients with Parkinson's disease (PD), and these deficits can be predicted by decreased frontal cortical 4-8 Hz theta activity that is associated with cognitive control. Previous work has shown that stimulating the subthalamic nucleus (STN) at theta frequencies via deep-brain stimulation (DBS) can improve cognitive control. Here we tested the neurocomputational hypothesis that stimulating STN theta activity increases decision thresholds, supporting more deliberate responding and nuanced adaptation under task trials that require cognitive control.
methodsWe tested 15 patients with PD receiving STN DBS at standard therapeutic frequencies ∼130 Hz and at 4 Hz while performing a Simon reaction-time task and applied computational diffusion decision modeling analyses to quantify the latent cognitive characteristic of response cautiousness via the well-established model parameter known as the decision threshold. This computational analysis better accounts for the speed-accuracy trade off when making deliberate choices.
resultsWe found that ∼130-Hz STN DBS decreased decision thresholds in line with our prior work, and we report new results showing that 4-Hz STN DBS increased decision thresholds.
conclusionsThese findings extend our knowledge of how the STN controls decision thresholds. Future work will study the STN's role in motor and cognitive control and how stimulating this region may modulate cognition in PD.
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