Evidence map›Paper›PMID 40373995›Full record

ArticleEnvironmental research2025

Maternal pre-pregnancy overweight/obesity, in-utero exposure to toxic heavy metals, and offspring age at peak height velocity: A prospective birth cohort study.

Aomi Katagiri, Zeyu Li, Guoying Wang, Pamela J Surkan, Xiaobin Wang, Takeo Fujiwara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aomi KatagiriDepartment of Public Health, Institue of Science Tokyo, Tokyo, Japan; Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Zeyu LiCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Guoying WangCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Pamela J SurkanDepartment of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Xiaobin WangCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Takeo FujiwaraDepartment of Public Health, Institue of Science Tokyo, Tokyo, Japan; Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. Electronic address: fujiwara.hlth@tmd.ac.jp.

Funding

Preterm Birth, Maternal and Cord Blood Metabolome, and Child Metabolic RiskR01HD041702 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI Frank B Hu, XIAOBIN WANG · 2001 to 2026
$11.1M
Immune Development Across the Life Course: Integrating Exposures and Multi-Omics in the Boston Birth CohortU01ES034983 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Hongkai Ji, Harry Benjamin Larman · 2022 to 2026
$3.9M
Functional RNA Modifications, Micronutrient Exposure, Developmental DisabilitiesR01ES031521 · NIEHS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI WANG, XIAOBIN, XIE, HEHUANG · 2020 to 2024
$1.9M
NICHD NIH HHS R01 HD041702NIEHS NIH HHS R01 ES031521NIEHS NIH HHS U01 ES034983
6 · The paper itself

Abstract

introductionResearch on in-utero heavy metal exposure shows inconsistent results on offspring pubertal timing. We aim to contribute to understanding the association between heavy metal exposures and age at peak height velocity (APHV), an indicator of pubertal timing, and to investigate the joint associations of heavy metal concentrations and previously known risk factors.

methodsWe included 956 mother-child dyads from the Boston Birth Cohort. Heavy metal concentrations were measured in maternal red blood cells collected 24-72 h after delivery. Offspring APHV was calculated using mixed-effects growth curve models based on repeated height measurements over time. Firstly, we investigated maternal lead, cadmium and mercury level in association with APHV using multivariate linear regression models. Secondly, we estimated the joint associations of maternal pre-pregnancy overweight/obesity (or race/ethnicity) and heavy metal concentrations with APHV, after adjusting for confounders. Thirdly, we applied a Bayesian kernel machine regression (BKMR) model to investigate the association between the heavy metal mixture and APHV.

resultsOverall, prenatal heavy metal exposure was modestly inversely (but not statistically significantly) associated with earlier offspring APHV. Both childhood and maternal pre-pregnancy overweight/obesity were associated with an earlier APHV. Non-Hispanic Black males had an earlier APHV than other race/ethnicity males. Moreover, high lead and cadmium concentrations and maternal pre-pregnancy overweight/obesity were jointly associated with APHV in males only and females only, respectively. The joint exposure of maternal pre-pregnancy overweight/obesity and high lead concentrations were associated with earlier APHV among males, and likewise maternal pre-pregnancy overweight/obesity and high cadmium concentrations with earlier APHV among females. The joint associations of non-Hispanic Black race/ethnicity and high concentrations of lead and mercury with APHV were observed in males.

conclusionsOur findings suggest that maternal pre-pregnancy overweight/obesity prevention and environmental toxic chemicals control may help attenuate the secular trend of early puberty, particularly among non-Hispanic Black individuals.

Indexed as

Body HeightEnvironmental PollutantsMaternal ExposureMetals, HeavyObesityOverweightPrenatal Exposure Delayed EffectsAdultBirth CohortBostonChildFemaleHumansMalePregnancyProspective StudiesEnvironmental PollutantsMetals, HeavyMetal toxicityOverweightPregnancyPrenatal exposurePubertal growthRace and ethnicity

Identifiers

PMID40373995
PMCPMC13316660

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.