ArticleJournal of clinical periodontology2025
Increasing Serum Vitamin D Levels Reduces Gingival Crevicular Fluid Matrix Metalloproteinase-9 Levels in Periodontal Health and Diseases.
Article in Journal of clinical periodontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Association between serum antibodies against oral microorganisms and vitamin D deficiency among US adults: A cross-sectional study.Medicine · 2026Article
- The Role of Vitamin DNutrients · 2026Review
- Interaction between vitamin D insufficiency and periodontitis, GCF vitamin D and LL-37 levels in well-controlled diabetes patients with periodontitis.European oral research · 2026Article
- Matrix Metalloproteinase-9 (MMP-9) as a Therapeutic Target: Insights into Molecular Pathways and Clinical Applications.Pharmaceutics · 2025Review
- Increasing Serum Vitamin D Levels Reduces Gingival Crevicular Fluid Matrix Metalloproteinase-9 Levels in Periodontal Health and Diseases.Journal of clinical periodontology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
aimsTo investigate whether restoring serum vitamin D levels in a population requiring supplementation affects matrix metalloproteinase-9 (MMP-9) levels in the gingival crevicular fluid (GCF) of individuals with periodontal health, gingivitis and periodontitis. MATERIALS AND
methodsThis prospective cohort study enrolled 101 participants with vitamin D deficiency, including those with periodontitis (34) and gingivitis (34) and healthy individuals (33). The periodontal status was evaluated using radiographic and clinical assessments of probing depth, clinical attachment loss, gingival index and plaque index. The analysis of MMP-9 levels in the GCF collected from the same dental sites was performed at baseline and 1 month post supplementation.
resultsAfter 1 month of vitamin D supplementation, a significant decrease in GCF MMP-9 levels was observed across all groups, with the most notable reduction observed in the periodontitis group. The healthy group exhibited the highest percentage reduction at 47%. Linear regression analysis confirmed that changes in vitamin D levels and pocket depth influenced MMP-9 alterations in the GCF.
conclusionsRestoration of vitamin D levels in vitamin D-deficient patients to the recommended average level (30 ng/mL), according to established guidelines, led to decreased MMP-9 levels in individuals with different periodontal statuses (healthy, gingivitis or periodontitis), potentially mitigating periodontal risks.
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