ArticleEuropean journal of dentistry2025
The Differences in Expression of Tumor Marker KI-67 and Proliferation Cell Nuclear Antigen (PCNA) in Ameloblastoma with Histopathological Subtypes Follicular, Plexiform, and Mixed (Follicular-Plexiform).
Article in European journal of dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Roburic Acid as a Therapeutic Candidate: Antiproliferative Activity and Secondary Cell Death Response in Colorectal Cancer Cells.International journal of molecular sciences · 2026Article
- A case report of multiple histological subtypes ameloblastoma with millet-like calcification.Frontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Ameloblastoma, though classified as a benign tumor, can induce deformities and functional abnormalities in the craniofacial region. Ki-67 is a typical marker for cell proliferation, with its expression peaking the M phase of the cell cycle or mitosis, indicating active cell division. Cells with high levels of Ki-67 expression are typically in a state of active proliferation. In addition, proliferating cell nuclear antigen (PCNA), a nuclear protein, plays a role in regulating the cell cycle and is involved in deoxyribonucleic acid (DNA) replication and repair processes. PCNA acts as a cofactor in DNA replication and repair processes.This study used 37 postoperative paraffin blocks for ameloblastoma patients in the period of 2015 to 2023. The samples in the inclusion criteria involved 24 samples with ameloblastomas diagnosis. Immunohistochemistries were used to observe the expression of Ki-67 and PCNA.The lowest expression of Ki-67 and PCNA was found in the plexiform subtype, whereas the highest expression values were found in mixed subtype (follicular-plexiform). The Tukey honestly significant difference test indicated a significant difference in Ki-67 expression in mixed subtypes compared to the plexiform and follicular types, with values of 0.001 (
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.