ArticleNature2025
Ku limits RNA-induced innate immunity to allow Alu expansion in primates.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Ku70-SAP domain has an overlapping function with DNA-PKcs in limiting the lateral movement of the Ku ring along DNA.Nucleic acids research · 2026Article
- Nonhomologous end joining-the importance of end tethering and beyond.Genes & development · 2026Review
- TGFβ1 Activates Lnc-APUE to Promote Tumor Metastasis via the Alu Element-Driven STAU1-Mediated Decay of CDH1 mRNA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Uncovering genetic interactions in the DNA repair network in response to endogenous damage and ionizing radiation.Cell reports · 2026Article
- Primate-specific adaptation of Ku protects transcriptomic integrity by suppressing Alu-mediated alternative splicing.bioRxiv : the preprint server for biology · 2025Article
- Ku limits aberrant mRNA splicing promoted by intronic antisense Alu elements.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
- Update of
Authors and funding
22 authors.
Yimeng ZhuInstitute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID 0000-0003-3186-7697
Angelina LiInstitute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Suvrajit MajiDepartment of System Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID 0000-0001-5547-1975
Brian J LeeInstitute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID 0000-0001-5550-1468
Sophie M KornDepartment of Biochemistry and Molecular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Jake A GertieDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID 0000-0002-3867-1884
Tyler J DorrityDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID 0000-0002-3780-6054
Jianhua WangDepartment of System Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Kyle J WangInstitute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Amandine PelletierDepartment of Genome Integrity, Cancer Research Center of Marseille, CNRS UMR7258, Inserm U1068, Institut Paoli-Calmettes, Aix Marseille Univiversité, Marseille, France.
Daniel F MoakleyDepartment of System Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Rachel D KellyDepartment of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Antony B HolmesInstitute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID 0000-0001-7559-2678
Raul RabadanDepartment of System Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
David R EdgellDepartment of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.ORCID 0000-0003-3858-6150
Caroline Schild-PoulterDepartment of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.ORCID 0000-0001-9943-9942
Mauro ModestiDepartment of Genome Integrity, Cancer Research Center of Marseille, CNRS UMR7258, Inserm U1068, Institut Paoli-Calmettes, Aix Marseille Univiversité, Marseille, France.ORCID 0000-0002-4964-331X
Anna-Lena SteckelbergDepartment of Biochemistry and Molecular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID 0000-0001-7988-9946
Eric A HendricksonDepartment of Medicine, Univeristy of Virginia Medical School, Charlottesville, VA, USA.
Hachung ChungDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Chaolin ZhangDepartment of System Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. cz2294@columbia.edu.ORCID 0000-0002-8310-7537
Shan ZhaInstitute for Cancer Genetics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. sz2296@cumc.columbia.edu.ORCID 0000-0002-6568-1818
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Parisa Tehranifar · 1985 to 2026
$115.3MThe Role of CTIP in Lymphocyte Development and LymphomagenesisP01CA174653 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RABADAN, RAUL · 2014 to 2024
$17.6MMedical Scientist Training ProgramT32GM145440 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEVEN L REINER · 2022 to 2026
$7.3MThe role of ATM in the suppression of lymphoid malignancyR01CA158073 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Shan Zha · 2011 to 2026
$5.7MTowards a quantitative understanding of tumor evolutionR35CA253126 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Raul Rabadan · 2021 to 2026
$5.6MComplexity and evolution of splicing-regulatory networksR35GM145279 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Chaolin Zhang · 2022 to 2026
$4.6MThe role of HPF1 in radiation and genotoxic cancer therapyR01CA293675 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Shan Zha · 2024 to 2026
$3.0MADVANCED GRADUATE TRAINING PROGRAM IN NEUROBIOLOGY & BEHAVIORT32NS064928 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HENGST, ULRICH · 2010 to 2024
$3.0MThe non-catalytic function of PARP2 in DNA repair and cancer therapyR01CA271595 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Shan Zha · 2022 to 2026
$2.9MThe role of DNA-PKcs in DNA repair, lymphocyte development, RNA metabolism and tumor suppressionR01CA275184 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Shan Zha · 2022 to 2026
$2.7MPOLQ- and CtIP-regulated telomere fusions and translocations are involved in early events in carcinogenesisR01CA266524 · NCI · UNIVERSITY OF VIRGINIA · PI HENDRICKSON, ERIC A · 2022 to 2025
$2.5MInvestigation of Self-Nucleic Acids as a Trigger for NeuroinflammationR01NS127802 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Hachung Chung · 2022 to 2026
$2.0MNCI NIH HHS P01 CA174653NCI NIH HHS P30 CA013696NCI NIH HHS R01 CA158073NCI NIH HHS R01 CA184187NCI NIH HHS R01 CA266524NCI NIH HHS R01 CA271595NCI NIH HHS R01 CA275184NCI NIH HHS R01 CA293675NCI NIH HHS R35 CA253126NIAID NIH HHS R21 AI171827NIAMS NIH HHS T32 AR076953NIGMS NIH HHS R35 GM145279NIGMS NIH HHS R35 GM150778NIGMS NIH HHS T32 GM145440NINDS NIH HHS R01 NS127802NINDS NIH HHS T32 NS064928
Abstract
Ku70 and Ku80 form the Ku heterodimer, a ring-shaped complex that initiates the non-homologous end-joining (NHEJ) DNA repair pathway
Indexed as
Alu ElementsImmunity, InnateKu AutoantigenPrimatesRNA, Double-StrandedAnimalsDNA End-Joining RepairFemaleHumansInterferonsMaleMiceNF-kappa BProto-Oncogene MasSignal TransductionInterferonsKu AutoantigenMAS1 protein, humanNF-kappa BProto-Oncogene MasRNA, Double-StrandedXrcc6 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.