Evidence map›Paper›PMID 40373771›Full record

ArticleImmunity2025

Heterozygosity for Crohn's disease risk allele of ATG16L1 promotes unique protein interactions and protects against bacterial infection.

Xiaomin Yao, Eugene Rudensky, Patricia K Martin, Brittany M Miller, Isabel Vargas, Erin E Zwack, Keenan A Lacey, Zhengxiang He, Glaucia C Furtado, Sérgio A Lira and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Autophagy and Bacterial infections.Autophagy reports · 2025
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaomin YaoDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Eugene RudenskyDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Patricia K MartinDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Brittany M MillerDivision of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Isabel VargasDivision of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Erin E ZwackDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Keenan A LaceyDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Zhengxiang HePrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Glaucia C FurtadoPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Sérgio A LiraPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Victor J TorresDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA; Antimicrobial-Resistant Pathogens Program, New York University Langone Health, New York, NY 10016, USA; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Bo ShopsinDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA; Antimicrobial-Resistant Pathogens Program, New York University Langone Health, New York, NY 10016, USA; Department of Medicine, Division of Infectious Diseases, New York University Grossman School of Medicine, New York, NY 10016, USA.
Ken CadwellDivision of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA. Electronic address: ken.cadwell@pennmedicine.upenn.edu.

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Richard Lewis Possemato · 1985 to 2026
$83.1M
Diabetes, Digestive, and Kidney Diseases Extramural ResearchR01DK093668 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2011 to 2026
$7.3M
Redefining the role of autophagy in bacterial diseaseR01AI121244 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2017 to 2026
$5.6M
The role of autophagy gene Atg16L1 in allogeneic hematopoietic stem cell transplantation - Resubmission - 1R01HL123340 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA, VAN DEN BRINK, MARCEL R M · 2015 to 2022
$5.2M
Mechanisms of MRSA intestinal colonizationR01AI140754 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHOPSIN, BO · 2020 to 2024
$3.5M
Regulation of the intestinal colonization niche by epithelial cell deathF32AI176810 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI MILLER, BRITTANY MARIE · 2023 to 2025
$202k
The Role of Autophagy During in vivo Salmonella InfectionF31DK111139 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARTIN, PATRICIA · 2016 to 2017
$88k
Modulation of host metabolism by a persistent enteric virusF31HL149238 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RUDENSKY, EUGENE · 2019 to 2020
$82k
NCI NIH HHS P30 CA016087NHLBI NIH HHS F31 HL149238NHLBI NIH HHS R01 HL123340NIAID NIH HHS F32 AI176810NIAID NIH HHS R01 AI121244NIAID NIH HHS R01 AI140754NIDDK NIH HHS F31 DK111139NIDDK NIH HHS R01 DK093668
6 · The paper itself

Abstract

The T300A substitution in ATG16L1 associated with Crohn's disease impairs autophagy, yet up to 50% of humans are heterozygous for this allele. Here, we demonstrate that heterozygosity for the analogous substitution in mice (Atg16L1

Indexed as

Autophagy-Related ProteinsCarrier ProteinsCrohn DiseaseSalmonella InfectionsSalmonella typhimuriumAllelesAnimalsAutophagyCytokinesGenetic Predisposition to DiseaseHeterozygoteHumansInflammasomesMacrophagesMiceMice, Inbred C57BLATG16L1 protein, humanAtg16l1 protein, mouseAutophagy-Related ProteinsCarrier ProteinsCytokinesInflammasomesATG16L1autophagybalancing selectionCrohn’s diseaseinflammasomeLC3-associated phagocytosisSalmonella

Identifiers

PMID40373771
PMCPMC12158642

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.