Evidence map›Paper›PMID 40373767›Full record

ArticleCell metabolism2025

Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV.

Jessica W Davidson, Raghav Jain, Thomas Kizzar, Gisela Geoghegan, Daniel J Nesbitt, Amy Cavanagh, Akira Abe, Kwamina Nyame, Andrea Hunger, Xiaojuan Chao and 14 more

Abstract read
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In one paragraph

Article in Cell metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Jessica W DavidsonDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Raghav JainDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Howard Hughes Medical Institute, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Thomas KizzarDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Gisela GeogheganDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Daniel J NesbittDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Amy CavanaghDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Akira AbeDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Kwamina NyameDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA; The Institute for Chemistry, Engineering & Medicine for Human Health (Sarafan ChEM-H), Stanford University, Stanford, CA 94305, USA.
Andrea HungerDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Xiaojuan ChaoDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Isabella JamesDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Helaina WalesewiczDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Dominique A BaldwinDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Howard Hughes Medical Institute, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Gina WadeDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Sylwia MichorowskaDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Drug Chemistry, Pharmaceutical and Biomedical Analysis, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.
Rakesh VermaDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Kathryn SchuelerDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Vania Hinkovska-GalchevaDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Evgenia ShishkovaDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Wen-Xing DingDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Joshua J CoonDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Morgridge Institute for Research, Madison, WI 53715, USA.
James A ShaymanDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Monther Abu-RemailehDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA; The Institute for Chemistry, Engineering & Medicine for Human Health (Sarafan ChEM-H), Stanford University, Stanford, CA 94305, USA.
Judith A SimcoxDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Howard Hughes Medical Institute, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address: jsimcox@wisc.edu.

Funding

Institutional Training in the Genomic SciencesT32HG002760 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI Qiongshi Lu · 2003 to 2026
$17.7M
TR&D 2 Metabolic Labels for Ultraplexed Protein Quantification p. 453P41GM108538 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$13.1M
Biology of Aging and Age-Related Diseases Training GrantT32AG000213 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Rozalyn M. Anderson, Sanjay Asthana · 1991 to 2026
$9.9M
Biotechnology Training ProgramT32GM135066 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI SCOTT M. COYLE, BRIAN G FOX · 2020 to 2026
$7.0M
Discovery and characterization of a novel acylcarnitine transporter in brown adipocytesR01DK133479 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Judith Anne Simcox · 2022 to 2026
$1.5M
NHGRI NIH HHS T32 HG002760NIA NIH HHS T32 AG000213NIDDK NIH HHS R01 DK133479NIGMS NIH HHS P41 GM108538NIGMS NIH HHS T32 GM135066
6 · The paper itself

Abstract

Cold exposure is a selective environmental stress that elicits a rapid metabolic shift to maintain energy homeostasis. In response to cold exposure, the liver rewires the metabolic state, shifting from glucose to lipid catabolism. By probing the liver lipids in cold exposure, we observed that the lysosomal bis(monoacylglycero)phosphate (BMP) lipids were rapidly increased during cold exposure. BMP lipid changes occurred independently of lysosomal abundance but were dependent on the lysosomal transcriptional regulator transcription factor EB (TFEB). Knockdown of Tfeb in hepatocytes decreased BMP lipid levels and led to cold intolerance in mice. We assessed TFEB-binding sites of lysosomal genes and determined that the phospholipase a2 group XV (PLA2G15) regulates BMP lipid catabolism. Decreasing Pla2g15 levels in mice increased BMP lipids, ablated the cold-induced rise in BMP lipids, and improved cold tolerance. Mutation of the catalytic site of PLA2G15 ablated the BMP lipid breakdown. Together, our studies uncover TFEB regulation of BMP lipids through PLA2G15 catabolism.

Indexed as

Cold TemperatureLipid MetabolismLiverLysophospholipidsMonoglyceridesPhospholipases A2AnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsHepatocytesLysosomesMaleMiceMice, Inbred C57BLBasic Helix-Loop-Helix Leucine Zipper Transcription Factorsbis(monoacylglyceryl)phosphateLysophospholipidsMonoglyceridesPhospholipases A2Tcfeb protein, mousebis(monoacylglycero)phosphateBMPcold exposureLC-MSlipidomicsliquid chromatography-mass spectrometryliverlysosomephospholipase A2 G15Pla2g15TFEBtranscription factor EB

Identifiers

PMID40373767
PMCPMC12136990

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.