Evidence map›Paper›PMID 40373765›Full record

ArticleStructure (London, England : 1993)2025

Structural insights from active site variants and β-8 loop interactions in viperin-like enzymes.

Jake C Lachowicz, Steven Grudman, Jeffrey B Bonanno, Andras Fiser, Tyler L Grove

Abstract read
In one paragraph

Article in Structure (London, England : 1993), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jake C LachowiczDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Steven GrudmanDepartment of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Jeffrey B BonannoDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Andras FiserDepartment of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Tyler L GroveDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: tyler.grove@einsteinmed.edu.

Funding

TRAINING PROGRAM IN CELLULAR &MOLEC. BIOLOGY &GENETICST32GM007491 · NIGMS · YESHIVA UNIVERSITY · PI QUERY, CHARLES C · 1985 to 2021
$17.0M
Molecular basis of recognition in the Immunological SynapseR35GM136357 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI FISER, ANDRAS · 2020 to 2024
$2.7M
Deciphering the role of ddhCTP in viperin-related functionsR01AI180133 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Tyler L Grove · 2024 to 2026
$2.2M
Interdisciplinary protein engineering approach to design high affinity antibodies for flavivirusesR01AI141816 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI FISER, ANDRAS · 2019 to 2023
$2.1M
NIAID NIH HHS R01 AI141816NIAID NIH HHS R01 AI180133NIGMS NIH HHS R35 GM136357NIGMS NIH HHS T32 GM007491
6 · The paper itself

Abstract

Viperin and viperin-like enzymes (VLEs) are members of the radical SAM superfamily that perform radical-mediated dehydrations on nucleoside triphosphates to yield 3'-deoxy-3',4'-didehydronucleoside triphosphates (ddhNTPs). Interestingly, viperin and VLEs demonstrate species-dependent substrate selectivity. Some fungal species have a second VLE and, while most viperin and VLEs contain an NΦHX

Indexed as

ProteinsAmino Acid SequenceAnimalsCatalytic DomainCrystallography, X-RayCytidine TriphosphateMiceModels, MolecularProtein BindingSubstrate SpecificityCytidine TriphosphateProteinsantiviralddhCTPddhUTPengineeringiron-sulfur clustersradical SAMViperin

Identifiers

PMID40373765
PMCPMC13288134

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.