ArticleRetina (Philadelphia, Pa.)2025
Fundus Autofluorescence (FAF) Alteration in Polypoidal Choroidal Vasculopathy (PCV) and Typical Neovascular Age Related Macular Degeneration (tAMD).
Article in Retina (Philadelphia, Pa.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Autofluorescence and deep learning in early disease detection: biological foundations, clinical applications, and future directions.Frontiers in artificial intelligence · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo characterize and evaluate differences in fundus autofluorescence (FAF) alteration in polypoidal choroidal vasculopathy (PCV) and typical neovascular age related macular degeneration (tAMD).
methodsWe used multimodal imaging to delineate the area of macular neovascularization (MNV) and extent of subretinal fluid (SRF). Macular FAF alteration was categorized to those limited to the area of the neovascular lesion (zone 1), area beyond zone 1 affected by subretinal fluid or pigment epithelial detachment (zone 2), and area beyond zone 2 (zone 3). Loss of FAF signal that correlated with complete outer retina and RPE loss (c-RORA) was documented.
resultsWe included 94 eyes from 94 patients (48 with diagnosis of PCV; 46 with diagnosis of tAMD). PCV eyes had greater subfoveal choroidal thickness (250 ± 92 μm vs 178 ± 86 μm, p<0.001) compared to tAMD. FAF alteration was seen in all eyes in Zone 1 and 2. Polypoidal lesion(s) appear as hyper-AF, iso-AF or hypo-AF round lesions. FAF alteration extending to zone 3 was observed in 41.7% of PCV eyes and 19.6% of tAMD eyes (p=0.02), in which hyper-AF pattern was predominant. Furthermore, zone 3 FAF alteration was associated with choroidal vascular hyperpermeability in eyes with PCV but not in tAMD (40% vs 0%, p=0.03).
conclusionThese findings highlight RPE dysfunction may affect widespread areas in PCV, and may be the effect of choroidal congestion.
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