Trial reportScience (New York, N.Y.)2025
Precise targeting of HIV broadly neutralizing antibody precursors in humans.
Abstract readClinical Trial, Phase IRandomized Controlled Trial
In one paragraph
Trial report in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Priming of Multiple HIV Neutralizing B Cell Precursors in Humans.medRxiv : the preprint server for health sciences · 2026Article
- Advances in Vaccines Against Infectious Diseases.Vaccines · 2026Article
- Overcoming immunogenic gaps in malaria subunit vaccines by broadening CSP regions targeted.The Journal of experimental medicine · 2026Article
- Learned young: HIV-1 germline-targeting vaccination in infants.Current opinion in HIV and AIDS · 2026Review
- Article
- Scientific synergy between prophylactic and therapeutic HIV vaccines-prevention and cure.NPJ vaccines · 2026Article
- Structure-based design of stable recombinant hepatitis C virus E1E2 heterodimers.Nature communications · 2026Article
- Non-human primate LIBRA-Seq accelerates neutralizing antibody discovery in RM vaccinated against HIV-1.PLoS pathogens · 2026Article
- Rapid boosting increases germinal center responses to sequential vaccines.Nature immunology · 2026Article
- VRC01-CLASS PRECURSOR FREQUENCY IN AN AFRICAN POPULATION IS INFLUENCED BY IGHV1-2 ALLELIC COMPOSITION AND NOT MALARIA EXPOSURE.Research square · 2026Article
- What's Hot in HIV in 2025-A Basic and Translational Science Review From IDWeek 2025.The Journal of infectious diseases · 2026Review
- Diverse germline-targeting HIV Env immunogens select for distinct mutations in the same knock-in mice B cell receptors.Nature communications · 2026Article
- Maturation of HIV-1 neutralizing antibodies in a germinal center conditional expression mouse model.PLoS pathogens · 2026Article
- HIV-1 BG505 SOSIP immunization induced B cell expansion targeting the 465-glycan hole, with neutralizing antibodies exhibiting distinct binding modes and mechanisms of virus inhibition.PLoS pathogens · 2026Article
- Recent advances in HIV-1 envelope-based vaccine designs for guiding broadly neutralizing antibody response.Journal of virology · 2026Review
- Safety and immunogenicity of an HIV envelope trimer immunogen that elicits CD4 binding site neutralizing antibody precursors (HVTN 300).medRxiv : the preprint server for health sciences · 2026Article
- Cell-free RNA reveals host and microbial correlates of broadly neutralizing antibody development against HIV.PLoS pathogens · 2026Article
- Decoding epitope immunodominance in HIV Env using cryoEM and machine learning.bioRxiv : the preprint server for biology · 2026Article
- Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading.Immunity · 2026Article
- Early clonal dominance at priming sets the trajectory for broad HIV serum neutralization.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
77 authors.
Tom G Caniels *Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.ORCID 0000-0001-9580-157X
Madhu Prabhakaran *Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-1981-9054
Gabriel OzorowskiDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0002-9695-8138
Kellie J MacPheeVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0009-0008-0993-4009
Weiwei WuVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0008-6015-9167
Karlijn van der StratenDepartment of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.ORCID 0000-0001-6373-9302
Sashank AgrawalDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0001-8549-9602
Ronald DerkingDepartment of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.
Emma I M M ReissDepartment of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.ORCID 0009-0006-4695-0628
Katrina MillardLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-2247-3178
Martina TurrojaLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-9640-0559
Aimee DesrosiersVaccine Research Unit, The George Washington University, Washington, DC, USA.ORCID 0009-0006-7576-4533
Jeffrey BethonyVaccine Research Unit, The George Washington University, Washington, DC, USA.
Elissa MalkinVaccine Research Unit, The George Washington University, Washington, DC, USA.ORCID 0000-0003-0943-5433
Marinus H LiesdekDepartment of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.
Annelou van der VeenDepartment of Internal Medicine, Amsterdam UMC, location AMC, Amsterdam, Netherlands.
Michelle KlouwensAmsterdam Institute for Immunology and Infectious Diseases, Amsterdam, Netherlands.ORCID 0000-0002-3515-6748
Jonne L SnitselaarDepartment of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.ORCID 0000-0002-2425-8335
Joey H BouhuijsDepartment of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.ORCID 0000-0002-6074-8542
Rhianna BronsonVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0009-5513-3250
Jalen Jean-BaptisteVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0008-5598-068X
Suprabhath GajjalaVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-3828-1958
Zahra Rikhtegaran TehraniVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-1127-1290
Alison BennerVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0009-0001-8864-4091
Mukundhan RamaswamiVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-4804-5676
Michael O DuffVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0009-0008-4279-0756
Yung-Wen LiuVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0003-0524-3952
Alicia H SatoVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0001-8371-8007
Ju Yeong KimVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0009-0002-1317-1223
Isabel J L BakenDepartment of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.ORCID 0009-0006-6818-1401
Catarina Mendes SilvaDepartment of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.ORCID 0009-0007-3419-2513
Tom P L BijlDepartment of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.
Jacqueline van RijswijkDepartment of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.
Judith A BurgerDepartment of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.
Albert CupoDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-7579-3525
Anila YasmeenDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-2386-8991
Swastik PhuleraDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0002-1272-7712
Wen-Hsin LeeDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0001-9445-6671
Kipchoge N RandallDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Shiyu ZhangDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0003-4586-0605
Martin M CorcoranDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-2774-0936
Isabel RegadasDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Alex C SullivanFoundation for the National Institutes of Health, Inc., Bethesda, MD, USA.
David M BrownFoundation for the National Institutes of Health, Inc., Bethesda, MD, USA.ORCID 0000-0003-4463-8316
Jennifer A BohlVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Kelli M GreeneDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.
Hongmei GaoDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-2468-8589
Nicole L YatesDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0003-2678-1311
Sheetal SawantDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-1109-7907
Jan M PrinsDepartment of Internal Medicine, Amsterdam UMC, location AMC, Amsterdam, Netherlands.
Neeltje A KootstraDepartment of Experimental Immunology, Amsterdam UMC, location AMC, Amsterdam, Netherlands.ORCID 0000-0001-9429-7754
Stephen M KaminskyDepartment of Genetic Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-1869-834X
Burc BarinThe Emmes Company, Rockville, MD, USA.
Farhad RahamanInternational AIDS Vaccine Initiative (IAVI), New York, NY, USA.ORCID 0000-0003-4069-4580
Margaret MellerInternational AIDS Vaccine Initiative (IAVI), New York, NY, USA.ORCID 0009-0007-4884-9088
Vince PhiliponisInternational AIDS Vaccine Initiative (IAVI), New York, NY, USA.ORCID 0009-0009-3287-382X
Dagna S LauferInternational AIDS Vaccine Initiative (IAVI), New York, NY, USA.ORCID 0009-0009-6888-8281
Angela LombardoInternational AIDS Vaccine Initiative (IAVI), New York, NY, USA.ORCID 0000-0003-0182-133X
Lindsey MwogaVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0009-0006-7601-9201
Solmaz ShotorbaniVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0009-0005-0016-6697
Drienna HolmanVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0009-0006-0595-7495
Richard A KoupVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-3090-7282
Per Johan KlasseDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-8222-278X
Gunilla B Karlsson HedestamDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7255-9047
Georgia D TomarasDepartment of Surgery, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0001-8076-1931
Marit J van GilsDepartment of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.ORCID 0000-0003-3422-8161
David C MontefioriFoundation for the National Institutes of Health, Inc., Bethesda, MD, USA.ORCID 0000-0003-0856-6319
Adrian B McDermottVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0616-9117
Ollivier HyrienVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0003-1909-2542
John P MooreDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-9902-6096
Ian A WilsonDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0002-6469-2419
Andrew B WardDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0001-7153-3769
David J DiemertVaccine Research Unit, The George Washington University, Washington, DC, USA.ORCID 0000-0002-2789-0512
Godelieve J de BreeDepartment of Internal Medicine, Amsterdam UMC, location AMC, Amsterdam, Netherlands.ORCID 0000-0002-5852-5833
Sarah F AndrewsVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-2583-1949
Marina CaskeyLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-1727-8693
Rogier W SandersDepartment of Medical Microbiology and Infection Prevention, Amsterdam UMC, location AMC, Amsterdam, Netherlands.ORCID 0000-0002-2324-8573
Funding
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUSAN JANET LITTLE · 1994 to 2026
$78.4MStructural studies of native-like SOSIP trimersP01AI110657 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI MOORE, JOHN P · 2015 to 2024
$35.4MNeutralization of Primate Immunodeficiency VirusesR01AI036082 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI JOHN P MOORE · 1994 to 2026
$4.3MGates Foundation INV-002202Gates Foundation INV-002916Gates Foundation INV-007368Gates Foundation INV-007371Gates Foundation INV-007375Gates Foundation INV-008017Gates Foundation INV-008352Gates Foundation INV-008818Gates Foundation INV-029691Gates Foundation INV-032929Gates Foundation INV-036842NIAID NIH HHS P01 AI110657NIAID NIH HHS P30 AI036214NIAID NIH HHS R01 AI036082
Abstract
A protective HIV vaccine will need to induce broadly neutralizing antibodies (bnAbs) in humans, but priming rare bnAb precursor B cells has been challenging. In a double-blinded, placebo-controlled phase 1 human clinical trial, the recombinant, germline-targeting envelope glycoprotein (Env) trimer BG505 SOSIP.v4.1-GT1.1, adjuvanted with AS01
Indexed as
AIDS VaccinesAntibodies, MonoclonalBroadly Neutralizing Antibodiesenv Gene Products, Human Immunodeficiency VirusHIV-1HIV AntibodiesHIV InfectionsAdjuvants, ImmunologicB-LymphocytesCD4 AntigensDouble-Blind MethodHumansSomatic Hypermutation, ImmunoglobulinAdjuvants, ImmunologicAIDS VaccinesAntibodies, MonoclonalBroadly Neutralizing AntibodiesCD4 Antigensenv Gene Products, Human Immunodeficiency VirusHIV AntibodiesVRC01 monoclonal antibody
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