Evidence map›Paper›PMID 40373113›Full record

ArticleScience (New York, N.Y.)2025

A wave of Thetis cells imparts tolerance to food antigens early in life.

Vanja Cabric, Yollanda Franco Parisotto, Tyler Park, Blossom Akagbosu, Zihan Zhao, Yun Lo, Gayathri Shibu, Logan Fisher, Yoselin A Paucar Iza, Christina Leslie and 1 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. [Gut microbiota and allergic diseases].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. RORγtNature communications · 2026
    Article
  17. RORγtScience immunology · 2026
    Article
  18. Dietary Antigen Interaction with Intestinal Epithelial Cells.Current allergy and asthma reports · 2026
    Review
  19. Neonatal liver niches program T cell tolerance.bioRxiv : the preprint server for biology · 2026
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vanja Cabric *Immuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0009-0004-8941-2083
Yollanda Franco Parisotto *Immuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-4598-8000
Tyler ParkComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-1246-1544
Blossom AkagbosuImmuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Zihan ZhaoImmuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0009-0003-8227-3108
Yun LoImmuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-8145-3674
Gayathri ShibuImmuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-4005-7450
Logan FisherImmuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-4680-1527
Yoselin A Paucar IzaImmuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Christina LeslieComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-4571-5910
Chrysothemis C BrownImmuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-5834-926X

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Deciphering the Genomics of Gene Network Regulation of T Cell and Fibroblast States in Autoimmune InflammationU01HG012103 · NHGRI · SLOAN-KETTERING INST CAN RESEARCH · PI Christina S Leslie, Alexander Y Rudensky · 2021 to 2026
$7.5M
Acceptance of non-self: Decoding intestinal immune tolerance during early lifeDP2AI171116 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI Chrysothemis Brown · 2022 to 2026
$2.7M
NCI NIH HHS P30 CA008748NHGRI NIH HHS U01 HG012103NIAID NIH HHS DP2 AI171116
6 · The paper itself

Abstract

In the intestine, peripherally induced regulatory T (pT

Indexed as

Antigen-Presenting CellsFood HypersensitivityImmune ToleranceT-Lymphocytes, RegulatoryAnimalsAntigensCell DifferentiationDietary ProteinsLymph NodesMesenteryMiceMice, Inbred C57BLOvalbuminWeaningAntigensDietary ProteinsOvalbumin

Identifiers

PMID40373113
PMCPMC13245555

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.