Evidence map›Paper›PMID 40373057›Full record

ArticleClinical transplantation2025

Trends, Clinical Characteristics, and Outcomes of Percutaneous Coronary Intervention in Liver Transplant Recipients.

Song Peng Ang, Jia Ee Chia, Jose Iglesias, Chayakrit Krittanawong

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Article in Clinical transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Song Peng AngDepartment of Medicine, Rutgers Health/Community Medical Center, Toms River, New Jersey, USA.ORCID https://orcid.org/0000-0001-8557-9880
Jia Ee ChiaDepartment of Medicine, Texas Tech University Health Science Center, El Paso, Texas, USA.
Jose IglesiasDepartment of Medicine, Rutgers Health/Community Medical Center, Toms River, New Jersey, USA.
Chayakrit KrittanawongHumanX, Delaware, Delaware, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronary artery disease (CAD) poses a significant challenge for liver transplant recipients (LTRs) who face higher cardiovascular risks due to immunosuppressive therapies and metabolic changes. While extensive research has focused on CAD management in patients awaiting liver transplantation, data on the outcomes of percutaneous coronary intervention (PCI) in the post-transplant population remain limited.

methodsThis retrospective cohort study used the National Inpatient Sample database (2016-2021) to evaluate PCI hospitalizations involving LTR and non-transplant patients. Propensity score matching (1:3) was applied to balance the covariates between the LTRs and non-transplant patients. The primary outcome was in-hospital mortality.

resultsAmong the 2 681 545 PCI hospitalizations, LTRs accounted for 0.1% (n = 2675). LTRs were more likely to have diabetes (60.56% vs. 41.36%) and chronic kidney disease (60.93% vs. 21.06%) but less likely to have hyperlipidemia (58.32% vs. 72.65%; all p < 0.001). The crude rates of AKI (32.34% vs. 16.07%; p < 0.001) and blood transfusion (5.61% vs. 2.76%; p = 0.0001) were higher in the LTRs. After matching, the LTRs were associated with lower odds of in-hospital mortality (OR, 0.55; 95% CI, 0.30-1.00; p = 0.05) and cardiogenic shock (OR, 0.46; 95% CI, 0.29-0.74; p = 0.001). PCI hospitalizations among LTRs increased over time, peaking in 2019 (116.6/100 000).

conclusionDespite higher comorbidities and complication rates, LTRs undergoing PCI exhibited lower in-hospital mortality than non-transplant patients, likely reflecting survivor bias, rigorous pre- and post-transplant care, and specialized management. These preliminary findings highlight the need for further studies with detailed clinical data to validate the current findings.

Indexed as

Coronary Artery DiseaseGraft RejectionLiver TransplantationPercutaneous Coronary InterventionPostoperative ComplicationsTransplant RecipientsAgedFemaleFollow-Up StudiesHospital MortalityHumansMaleMiddle AgedPrognosisRetrospective StudiesRisk Factorscardiovascular outcomescoronary artery diseasecoronary interventionimmunosuppressantliver transplant

Identifiers

PMID40373057
PMCPMC12080875

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.