SynthesisJMIR mental health2025
Evaluating Generative AI in Mental Health: Systematic Review of Capabilities and Limitations.
Synthesis in JMIR mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Therapeutic Interaction Features of AI Chatbots in Depression Interventions: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Artificial intelligence in mental health care: a scoping review of reviews.Frontiers in psychiatry · 2026Pooled it
- Large language models' performance in answering common patient questions about colonoscopy: an expert-based evaluation.BMC gastroenterology · 2026Observational
- Are You Qualified, ChatGPT? Examining Clinical Skills and Competencies of ChatGPT in Delivering Systemic Interventions.Journal of marital and family therapy · 2026Article
- Making medical AI benchmarks clinically interpretable: the case of mental health.BMJ mental health · 2026Article
- Psychological Therapy in the Age of Large Language Models: Framework for Therapist-Delivered and AI-Supported Functions.JMIR mental health · 2026Article
- Consumer and Patient Health Information Seeking With Generative AI Tools: Scoping Review of Facilitators and Barriers.Journal of medical Internet research · 2026Article
- Exploring Real-World Use of AI Chatbots for Mental Health Support: Cross-Sectional Survey Study.JMIR mental health · 2026Article
- Large Language Model-Based Behavioral Activation Chatbot for Young People With Depression Using Artificial Users and Clinical Experts: Mixed Methods Evaluation.JMIR mental health · 2026Article
- General-Purpose Artificial Intelligence Use in Routine Mental Health Practice Among Australian Clinicians: Mixed Methods Study.Journal of medical Internet research · 2026Article
- Generative Large Language Models in Mental Health Care Settings: Systematic Review and Meta-Analysis.JMIR AI · 2026Review
- Perceived Support Is Not Psychological Change: Reframing AI Chatbots in Mental Health Care.JMIR AI · 2026Article
- Large Language Models for Mental Health Prediction: Scoping Review of Bias and Clinical Utility Documentation in 2019-2024.JMIR AI · 2026Review
- Strengths and Potential Pitfalls of the Use of Artificial Intelligence in Psychiatric Education and Practice.Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry · 2026Article
- Applications of human-machine collaborative decision-making: A review of research with recent developments.iScience · 2026Review
- Mapping Practice-Based Signals of Generative AI in Psychiatric Care: Qualitative Study of Korean Psychiatrists' Experiences, Interpretations, and Implementation Priorities.Journal of medical Internet research · 2026Article
- Efficacy of AI-delivered cognitive behavioral therapy interventions for anxiety and depressive symptoms: a systematic review.NPJ digital medicine · 2026Article
- When AI Colludes: Clinical Reliability of Training and Preference Data as a Trustworthy-AI Criterion.JMIR mental health · 2026Article
- Evaluating the performance of ChatGPT in responding to myotonic dystrophy type 1 patient inquiries: a specialist physician-based study.BMC neurology · 2026Article
- Exploring Nurses' Perspectives on the Use of Artificial Intelligence Chatbots for Mental Health Support: A Cross-Sectional Study in Greece.Nursing reports (Pavia, Italy) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The global shortage of mental health professionals, exacerbated by increasing mental health needs post COVID-19, has stimulated growing interest in leveraging large language models to address these challenges. objectives: This systematic review aims to evaluate the current capabilities of generative artificial intelligence (GenAI) models in the context of mental health applications. Methods: A comprehensive search across 5 databases yielded 1046 references, of which 8 studies met the inclusion criteria. The included studies were original research with experimental designs (eg, Turing tests, sociocognitive tasks, trials, or qualitative methods); a focus on GenAI models; and explicit measurement of sociocognitive abilities (eg, empathy and emotional awareness), mental health outcomes, and user experience (eg, perceived trust and empathy). Results: The studies, published between 2023 and 2024, primarily evaluated models such as ChatGPT-3.5 and 4.0, Bard, and Claude in tasks such as psychoeducation, diagnosis, emotional awareness, and clinical interventions. Most studies used zero-shot prompting and human evaluators to assess the AI responses, using standardized rating scales or qualitative analysis. However, these methods were often insufficient to fully capture the complexity of GenAI capabilities. The reliance on single-shot prompting techniques, limited comparisons, and task-based assessments isolated from a context may oversimplify GenAI's abilities and overlook the nuances of human-artificial intelligence interaction, especially in clinical applications that require contextual reasoning and cultural sensitivity. The findings suggest that while GenAI models demonstrate strengths in psychoeducation and emotional awareness, their diagnostic accuracy, cultural competence, and ability to engage users emotionally remain limited. Users frequently reported concerns about trustworthiness, accuracy, and the lack of emotional engagement. Conclusions: Future research could use more sophisticated evaluation methods, such as few-shot and chain-of-thought prompting to fully uncover GenAI's potential. Longitudinal studies and broader comparisons with human benchmarks are needed to explore the effects of GenAI-integrated mental health care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.