SynthesisPloS one2025
Incidence of intensive care unit acquired weakness in critically ill patients treated with kidney replacement therapy: A systematic review and meta-analysis.
Synthesis in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Dynamic changes in quadriceps and diaphragm thickness for early diagnosis of ICU-acquired weakness in elderly ICU patients: a prospective bedside ultrasound study.Frontiers in medicine · 2026Article
- Perme Score and Machine Learning for Detecting ICU-acquired Weakness: A Prospective Observational Cohort Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study assesses the incidence of ICU-acquired weakness (ICUAW) among patients using kidney replacement therapy (KRT) and explores the uncertain relationship between KRT and ICUAW in critically ill adult patients.
methodsA comprehensive search was conducted across PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials up to June 10, 2024. Inclusion criteria encompassed randomized controlled trials (RCTs), as well as prospective and retrospective cohort studies that examined the correlation between KRT and ICUAW in adult ICU patients. Heterogeneity was evaluated using the χ² and I² statistics. Publication bias was assessed qualitatively via funnel plots and quantitatively using Begg's and Egger's tests.
resultsA total of twelve cohort studies involving 2275 adult patients were included, with no RCTs meeting the criteria. The overall incidence of ICUAW was 49.5% in patients using KRT, compared to 34.8% in non-KRT controls. These studies collectively demonstrated a statistically significant association between KRT and a higher incidence of ICUAW (OR, 2.12; 95% CI, 1.34-3.34). Subgroup and sensitivity analyses reinforced this association, particularly in studies involving patients with clinical weakness, large sample sizes, and low risk of bias. However, studies focused on patients with abnormal electrophysiology and small sample sizes did not show this correlation. Despite the substantial findings, statistical heterogeneity was present. No significant publication bias was detected.
conclusionThis study highlights a significant association between KRT and an increased incidence of developing ICUAW.
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