ArticleCell reports2025
The ventral CA2 region of the hippocampus and its differential contributions to social memory and social aggression.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Intranasal Vasopressin Decreases Voluntary Ethanol Drinking in Single- and Group-Housed Mice Through Mechanisms Involving Vasopressin 1a and 1b Receptors.Alcohol, clinical & experimental research · 2026Article
- Article
- Protocol for whole-cell patch-clamp recording and post hoc identification of hippocampal CA2 pyramidal neurons in adult mouse brain slices.STAR protocols · 2026Article
- Hippocampal CA2 modulates trace fear conditioning through circuit-specific control of CA1.bioRxiv : the preprint server for biology · 2026Article
- Emotional shaping of spatial encoding along the dorsal ventral axis of the hippocampus.Frontiers in systems neuroscience · 2026Review
- Connectivity and phenotype of vasopressin 1a receptor cells in the lateral septum.bioRxiv : the preprint server for biology · 2025Article
- Hippocampal CA2 to CA1: A metaplastic switch for memory encoding.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A circuit from the basolateral amygdala to hippocampal CA3 regulates social behavior.Current biology : CB · 2025Article
- Differentiated Presynaptic Input to OLMɑ2 Cells Along the Hippocampal Dorsoventral Axis: Implications for Hippocampal Microcircuit Function.Hippocampus · 2025Article
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Authors and funding
9 authors.
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Abstract
The dorsal and ventral regions of the CA1 field of the hippocampus play distinct roles in the encoding of cognitive vs. emotional behaviors, respectively. Whether this distinction applies to other hippocampal fields and other behaviors is unclear. Here, we focus on the hippocampal CA2 field and compare the properties and behavioral roles of its dorsal (dCA2) and ventral (vCA2) regions. Although dCA2 is known to be required for social memory and to promote social aggression, the role of vCA2 is unknown. We report that a defined CA2 region extends to the extreme ventral pole of the hippocampus, with certain distinctions to dCA2. Unlike dCA2, chemogenetic silencing of vCA2 pyramidal neurons did not impair social memory. Similar to dCA2, vCA2 was required to promote social aggression. Thus, consistent with the CA1 region, CA2 may be differentially tuned to support cognitive compared with emotional processes along its dorsal to ventral axis.
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