ArticleEpilepsia2025
Seizure-onset zone lateralization in temporal lobe epilepsy using 7T rs-fMRI: Direct comparison with 3T rs-fMRI.
Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- The dynamic functional connectivity peak index: Detection of interictal epileptic activity with fMRI.Epilepsia · 2026Article
- A multimodal epilepsy dataset of paired 3-Tesla and 7-Tesla MRI and intracranial EEG.Scientific data · 2026Article
- Lateralization of FDG-PET Hypometabolism Using Resting-State fMRI in Temporal Lobe Epilepsy: A Simultaneous PET-MRI Study.Tomography (Ann Arbor, Mich.) · 2026Article
- Seizure-onset zone lateralization in temporal lobe epilepsy using 7T rs-fMRI: Direct comparison with 3T rs-fMRI.Epilepsia · 2025Article
- 7 tesla multiscale entropy analysis reveals increased resting-state complexity in key regions for fear and anxiety in spider-fearful individuals.NeuroImage · 2025Article
- MRI based early Temporal Lobe Epilepsy detection using DGWO based optimized HAETN and Fuzzy-AAL Segmentation Framework (FASF).PloS one · 2025Article
- Excitatory-inhibitory imbalance in temporal lobe epilepsy: a 5T multimodal MRI biomarker for focus localization and drug resistance stratification.Frontiers in aging neuroscience · 2025Article
- Connectivity of the Piriform Cortex and its Implications in Temporal Lobe Epilepsy.medRxiv : the preprint server for health sciences · 2024Article
- 7 T and beyond: toward a synergy between fMRI-based presurgical mapping at ultrahigh magnetic fields, AI, and robotic neurosurgery.European radiology experimental · 2024Review
Corrections and comments
- Update of
Authors and funding
9 authors.
Funding
Abstract
objectiveResting-state functional magnetic resonance imaging (rs-fMRI) at ultra-high field strengths (≥7T) is known to provide superior signal-to-noise to comparable acquisitions at lower field strengths. In this study, we provide a direct comparison of the seizure onset-zone (SOZ) lateralizing ability of 7T rs-fMRI and 3T rs-fMRI.
methodsWe investigated a cohort of 70 patients with temporal lobe epilepsy (TLE). A paired cohort of 19 patients had 3T and 7T rs-fMRI acquisitions for direct comparison between the two field strengths. Forty-three patients had only 3T, and eight patients had only 7T rs-fMRI acquisitions. We quantified the functional connectivity between the hippocampus and other nodes within the default mode network (DMN) using seed-to-voxel connectivity, and measured how hippocampal-DMN connectivity could inform SOZ lateralization at 7T and 3T field strengths.
resultsDifferences in hippocampal-DMN connectivity ipsilateral and contralateral to the SOZ were significantly higher at 7T (Cohen's d = 0.51, p = 0.008) than at 3T (Cohen's d = 0.26, p = 0.68) when measured in the same subjects. We found that SOZ lateralization was superior at 7T (receiver-operating characteristic area under the curve [ROC AUC] = 0.97, 95% confidence interval [CI]: 0.92-1.00) than 3T (ROC AUC = 0.67, 95% CI: 0.36-0.98), for the same subjects scanned at both field strengths. Our findings were reproduced in extended cohorts of subjects scanned at either 3T or 7T. Our rs-fMRI findings at 7T, but not 3T, are consistent (Spearman ρ = 0.65, p = .01) with clinical fluorodeoxyglucose positron emission tomography (FDG-PET) lateralizing hypometabolism. SIGNIFICANCE: We show superior SOZ lateralization in patients with TLE when using 7T relative to 3T rs-fMRI, supporting the adoption of high field strength functional imaging in the epilepsy presurgical evaluation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.