Evidence map›Paper›PMID 40372775›Full record

ArticleeLife2025

Rudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development.

Divyesh Joshi, Preeti Jindal, Ronak K Shetty, Maneesha S Inamdar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Divyesh Joshi *Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India.ORCID https://orcid.org/0000-0002-4415-2677
Preeti Jindal *Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India.
Ronak K ShettyJawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India.
Maneesha S InamdarJawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India.ORCID https://orcid.org/0000-0002-8243-2821

Funding

Department of Biotechnology, Ministry of Science and Technology, India Sanction no. BT/PR11246/BRB/10/644/2008 dated 29.09.2009JC Bose Fellowship JCB/2019/000020Wellcome TrustWellcome Trust 10.35802/094879
6 · The paper itself

Abstract

The transforming growth factor β (TGFβ) signaling pathway is critical for survival, proliferation, and cell migration, and is tightly regulated during cardiovascular development. Smads, key effectors of TGFβ signaling, are sequestered by microtubules (MTs) and need to be released for pathway function. Independently, TGFβ signaling also stabilizes MTs. Molecular details and the in vivo relevance of this cross-regulation remain unclear, understanding which is important in complex biological processes such as cardiovascular development. Here, we use

Indexed as

Cell Cycle ProteinsMicrotubulesSignal TransductionTransforming Growth Factor betaAnimalsCell MovementEndothelial CellsHumansMiceProto-Oncogene MasSmad2 ProteinCell Cycle ProteinsMAS1 protein, humanProto-Oncogene MasSmad2 ProteinTransforming Growth Factor betaBCAS3cell biologydevelopmental biologymicrotubule cytoskeletonmouseRudhiraSmad2/3TGFβ signaling

Identifiers

PMID40372775
PMCPMC12080998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.